Regenerating nodules in hepatic cirrhosis: MR findings with pathologic correlation.

Regenerating nodules in hepatic cirrhosis: MR findings with pathologic correlation. Research Abstract Details 

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Regenerating nodules in hepatic cirrhosis: MR findings with pathologic correlation. Abstract Text:

T Murakami,C Kuroda,T Marukawa,K Harada,K Wakasa,M Sakurai,M Monden,A Kasahara,S Kawata,T Kozuka,

To establish clearly the pathologic basis for small low-intensity nodules seen on MR images of the cirrhotic liver, we obtained MR images in 26 patients with cirrhosis in whom partial hepatectomy for hepatoma (15 patients), laparoscopy for cirrhosis (10 patients), or autopsy (one patient) was subsequently performed. Small low-intensity nodules were seen on gradient-echo images with short TEs (10-13 msec) in 13 of the 26 patients. In 12 of these 13 patients, small low-intensity nodules appeared larger and clearer as the TE was prolonged (14-25 msec). On T2-weighted spin-echo images, small low-intensity nodules were seen in 12 of the 13 patients, but not seen as well as on gradient-echo images. Pathologic correlation in these 13 patients revealed that the nodules on the MR images corresponded to iron deposits in regenerating nodules. Small low-intensity nodules were observed only on T2-weighted spin-echo images in two of the remaining 13 patients, in whom microscopic examination of the liver revealed marked inflammatory cell infiltration in the fibrous septa and no iron deposition. We conclude that small low-intensity nodules observed on MR images are caused by iron deposits in regenerating nodules, and that gradient-echo images with short and prolonged TEs are useful to confirm the presence of iron deposits in regenerating nodules.

Regenerating nodules in hepatic cirrhosis: MR findings with pathologic correlation. Publishing Authors By Initials

T Murakami,C Kuroda,T Marukawa,K Harada,K Wakasa,M Sakurai,M Monden,A Kasahara,S Kawata,T Kozuka,

For similar persons: age groups: adult: middle aged research abstracts see: persons: age groups: adult: middle aged research

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Regenerating nodules in hepatic cirrhosis: MR findings with pathologic correlation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJR. American journal of roentgenology

VOLUME: 155

Page Numbers: 1227-31

Journal Abbreviation:

ISSN: 0361-803X

DAY: 15

MONTH: Dec

YEAR: 1990

Regenerating nodules in hepatic cirrhosis: MR findings with pathologic correlation. Information

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LANGUAGE: eng

NlmUniqueID: 7708173

Regenerating nodules in hepatic cirrhosis: MR findings with pathologic correlation. Keywords Mesh Terms:

KEYWORDS: Middle Aged

MESH TERMS: physiology

Chemical & Substance for Abstract: Regenerating nodules in hepatic cirrhosis: MR findings with pathologic correlation. Information

Substance Name: Iron

Registry Number: 7439-89-6

Grant and Affiliation Information for Regenerating nodules in hepatic cirrhosis: MR findings with pathologic correlation.

AFFILIATION: Department of Radiology, Osaka University Medical School, Japan.

Country: UNITED STATES

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MEDLINETA: AJR Am J Roentgenol

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