Regenerating cochlear hair cells: quo vadis stem cell.

Regenerating cochlear hair cells: quo vadis stem cell. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regenerating cochlear hair cells: quo vadis stem cell. Abstract Text:

Many elderly people worldwide lose the neurosensory part of their ear and turn deaf. Cochlear implants to restore some hearing after neurosensory hearing loss are, at present, the only therapy for these people. In contrast to this therapy, replacement of hair cells via stem cell therapies holds the promise for a cure. We review here current insights into embryonic, adult, and inducible stem cells that might provide cells for seeding the cochlea with the hope of new hair cell formation. We propose a two-step approach using a first set of transcription factors to enhance the generation of inducible pluripotent stem (iPS) cells and a second set of factors to initiate the differentiation of hair cells. Recent evidence regarding ear development and stem cell research strongly suggest that microRNAs will be an important new regulatory factor in both iPS cell formation and differentiation to reprogram cells into hair cells. In addition, we highlight currently insurmountable obstacles to the successful transformation of stem cells into hair cell precursors and their injection into the cochlear canal to replace lost hair cells.

Regenerating cochlear hair cells: quo vadis stem cell. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Regenerating cochlear hair cells: quo vadis stem cell. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell and tissue research

VOLUME: 333

Page Numbers: 373-9

Journal Abbreviation: Cell Tissue Res.

ISSN: 0302-766X

DAY: 25

MONTH: 06

YEAR: 2008

Regenerating cochlear hair cells: quo vadis stem cell. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 417625

Regenerating cochlear hair cells: quo vadis stem cell. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Regenerating cochlear hair cells: quo vadis stem cell. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Regenerating cochlear hair cells: quo vadis stem cell.

AFFILIATION: Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cell Tissue Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regenerating cochlear hair cells: quo vadis stem cell Related Publications

• Adaptations of the vestibular system to short and long-term exposures to altered gravity.
• Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation.
• Long-Distance Three-Color Neuronal Tracing in Fixed Tissue Using NeuroVue Dyes.
• Molecular developmental neurobiology of formation, guidance and survival of primary vestibular neurons.
• Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation.
• Regenerating cochlear hair cells: quo vadis stem cell.
• Stem cells and molecular strategies to restore hearing.
• The molecular biology of ear development - "Twenty years are nothing".
• [Clinical experience with the "Grevimun" immunologic pregnancy test (SSW)]
• [Fundus changes in late toxemias of pregnancy]
• [Graduation of gynecological findings from the social-gynecological and industrial health viewpoint (author's transl)]
• [Homeoplastic endometrium transplantations at the Berlin University Gynecologic Clinic (Charité) during 1948-1968]
• [Malate dehydrogenase determination in obstetrics]
• [Noise and pregnancy (author's transl)]
• [On labor induction by intravenous estrogen administration]
• [On the morphology and clinical course of placenta increta]
• [Results of sociogynaecological examination for fitness of working women (author's transl)]
• [Serum activity of alkaline and acid phosphatase in pregnancy and during delivery]
• [Serum activity of transaminase (SGOT, SGPT) and lactate dehydrogenase (SLDH) in normal pregnancy and during delivery]
• [The TTC-test as screening test for the determination of bacteriurias in pregnancy]
• [The use of controlled hypothermia in the treatment of eclampsia]