REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells.

REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. Research Abstract Details 

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REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. Abstract Text:

Akira Sekikawa,Hirokazu Fukui,Shigehiko Fujii,Kazuhito Ichikawa,Shigeki Tomita,Johji Imura,Tsutomu Chiba,Takahiro Fujimori,Akira Sekikawa,Hirokazu Fukui,Shigehiko Fujii,Kazuhito Ichikawa,Shigeki Tomita,Johji Imura,Tsutomu Chiba,Takahiro Fujimori,

Signal transducer and activator of transcription 3 (STAT3) signaling plays roles in inflammation-associated carcinogenesis. Regenerating gene (REG) Ialpha protein, an interleukin (IL)-6-inducible gene, is suggested to be involved in the gastritis-gastric cancer sequence. We investigated the involvement of IL-6/STAT3 signaling in REG Ialpha protein expression and examined whether REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. The effects of IL-6/STAT3 signaling on REG Ialpha protein expression were examined using a STAT3 small interfering RNA system in gastric cancer cells. The element responsible for IL-6-induced REG Ialpha promoter activation was determined by a promoter deletion assay. The anti-apoptotic effects of STAT3 signaling and its induced REG Ialpha protein were examined by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphatase nick-end labeling and caspase assay in vitro. Human gastric cancer specimens were analyzed by immunohistochemistry for phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and REG Ialpha protein. IL-6 treatment enhanced the expression of REG Ialpha protein through STAT3 activation in gastric cancer cells. The IL-6-responsive element was determined to lie in the sequence from -142 to -134 of the REG Ialpha promoter region. REG Ialpha protein mediated the anti-apoptotic effects of STAT3 signaling in gastric cancer cells by enhancing Akt activation, Bad phosphorylation and Bcl-xL expression. The expression of REG Ialpha protein was significantly correlated with that of p-STAT3 in gastric cancer tissues. REG Ialpha protein may play a pivotal role in anti-apoptosis in gastric tumorigenesis under STAT3 activation.

REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. Publishing Authors By Initials

A Sekikawa,H Fukui,S Fujii,K Ichikawa,S Tomita,J Imura,T Chiba,T Fujimori,A Sekikawa,H Fukui,S Fujii,K Ichikawa,S Tomita,J Imura,T Chiba,T Fujimori,

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REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Carcinogenesis

VOLUME: 29

Page Numbers: 76-83

Journal Abbreviation: Carcinogenesis

ISSN: 1460-2180

DAY: 16

MONTH: 11

YEAR: 2007

REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. Information

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LANGUAGE: eng

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Grant and Affiliation Information for REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells.

AFFILIATION: Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine 880 Kitakobayshi, Mibu, Shimotsuga, Tochigi 321-0293, Japan.

Country: England

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MEDLINETA: Carcinogenesis

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