Refining the roles of GABAergic signaling during neural circuit formation.

Refining the roles of GABAergic signaling during neural circuit formation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Refining the roles of GABAergic signaling during neural circuit formation. Abstract Text:

Colin J Akerman,Hollis T Cline,

Our understanding of the role of GABA signaling in circuit development is rapidly expanding. Here, we review three recent refinements in our understanding of the diverse roles that GABA plays at different stages of neural circuit formation. First, we discuss recent evidence that depolarizing GABA plays at least a permissive role in promoting both excitatory and inhibitory synaptogenesis in developing neurons (including newly generated neurons in the adult). Next, we discuss recent evidence that GABAergic circuits sculpt the temporal and spatial aspects of synaptic integration. Consequently, early developmental events affecting the establishment of GABAergic circuits will control subsequent activity-dependent refinements of information processing and circuit function. In the third section, we review recent evidence of molecular mechanisms by which GABAergic signaling plays a role in the regulation of the balance between GABAergic and glutamatergic transmission in developing circuits. Throughout the review, we concentrate on the effects of the signaling by GABA(A) receptors, as told from the point of view of the GABA-responsive cells, and do not discuss mechanisms that govern GABA release or activity of GABAergic neurons per se.

Refining the roles of GABAergic signaling during neural circuit formation. Publishing Authors By Initials

CJ Akerman,HT Cline,

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research

PUBMED ID PMID:

MEDLINE DATE:

Refining the roles of GABAergic signaling during neural circuit formation. Journal Published:

PUBLICATION TYPE: Review

Journal: Trends in neurosciences

VOLUME: 30

Page Numbers: 382-9

Journal Abbreviation: Trends Neurosci.

ISSN: 0166-2236

DAY: 27

MONTH: 06

YEAR: 2007

Refining the roles of GABAergic signaling during neural circuit formation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7808616

Refining the roles of GABAergic signaling during neural circuit formation. Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: physiology

Chemical & Substance for Abstract: Refining the roles of GABAergic signaling during neural circuit formation. Information

Substance Name: Glutamic Acid

Registry Number: 56-86-0

Grant and Affiliation Information for Refining the roles of GABAergic signaling during neural circuit formation.

AFFILIATION: Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK, OX1 3QT.

Country: England

AGENCY: United Kingdom Wellcome T

GRANT: OD000458

ACRONYM: OD

MEDLINETA: Trends Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Refining the roles of GABAergic signaling during neural circuit formation Related Publications

• 3DFT MR angiography of carotid and basilar arteries.
• A correlated study of tuberculin, histoplasmin and coccidioidin sensitivities with pulmonary calcifications in the Rocky Mountain area.
• A day in the life of an orthodontic assistant.
• Adrenal steroids in leukemia and lymphoma.
• Biotechnology and the new right: a progressive red herring?
• Cesium-137 movement in a root-soil profile. BNWL-480.
• Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion.
• Decreases in plasma volume during electrically induced convulsions in man.
• Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis).
• Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys.
• Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model.
• Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys.
• Effects of soybean glyceollins and estradiol in postmenopausal female monkeys.
• Effects of tibolone on estrogen biosynthesis in the mammary tissue of postmenopausal monkeys.
• Gold foil; the class five restoration.
• Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys.
• Insertion of drug resistance genes in animals.
• Mammary gland development in early pubertal female macaques.
• Radioiodine environment release studies. BNWL-280.
• Reaching kids with reactive attachment disorder.
• Refining the roles of GABAergic signaling during neural circuit formation.
• Roles of NR2A and NR2B in the Development of Dendritic Arbor Morphology In Vivo.
• Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys.
• Technology and outpatient review: a preliminary evaluation.
• The management of retained placenta; a plea for manual removal.
• The menace of socialized medicine.
• The thylakoid proton gradient promotes an advanced stage of signal peptide binding deep within the Tat pathway receptor complex.
• [Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)]
• [Incidence and clinical features of arrhythmias after surgical treatment of congenital heart disease]
• beta-Melanocyte-Stimulating Hormone Potently Reduces Appetite Via the Hypothalamus in Chicks.