Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon.

Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. Research Abstract Details 

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Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. Abstract Text:

Akemi Hoshino,Hodaka Fujii,

Cytokines control cell differentiation, proliferation, and function by regulating gene expression program. Physiological roles and induction mechanisms of cytokine-inducible genes are not fully understood. Here, we identified a novel immediate-early cytokine-responsive gene, cyclon (cytokine-induced protein with coiled-coil domain), which is induced in a hematopoietic cell line by interleukin 3 (IL-3). cyclon gene encodes a phosphorylated nuclear protein consisting of repetitive sequences in the amino-terminus and a coiled-coil domain in the carboxyl-terminus. A novel transient reporter assay revealed that mouse cyclon promoter contains redundant elements for IL-3-induced gene expression.

Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. Publishing Authors By Initials

A Hoshino,H Fujii,

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Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: FEBS letters

VOLUME: 581

Page Numbers: 975-80

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 7

MONTH: 02

YEAR: 2007

Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. Information

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LANGUAGE: eng

NlmUniqueID: 155157

Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. Keywords Mesh Terms:

KEYWORDS: Suppressor of Cytokine Signaling Protein

MESH TERMS: metabolism

Chemical & Substance for Abstract: Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. Information

Substance Name: cytokine inducible SH2-containing protei

Registry Number: 0

Grant and Affiliation Information for Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon.

AFFILIATION: Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB-126, New York, NY 10016, USA.

Country: Netherlands

AGENCY: United States NIAID

GRANT: R01 AI059315-03

ACRONYM: AI

MEDLINETA: FEBS Lett

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