Reduction of serum ghrelin concentration during interferon-alpha therapy in patients with chronic hepatitis C.

Reduction of serum ghrelin concentration during interferon-alpha therapy in patients with chronic hepatitis C. Research Abstract Details 

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Reduction of serum ghrelin concentration during interferon-alpha therapy in patients with chronic hepatitis C. Abstract Text:

Hisayoshi Watanabe,Takafumi Saito,Testuru Karasawa,Shun Kudo,Kuniaki Nakano,Jun-Itsu Ito,Kazuhiko Sugahara,Koji Saito,Hitoshi Togashi,Sumio Kawata,

The efficacy of interferon (IFN) therapy for chronic hepatitis C is dependent on compliance. Anorexia is an important adverse effect in determining compliance. To clarify the mechanisms underlying anorexia, the level of ghrelin was determined during therapy. Fourteen patients with chronic hepatitis C received IFN-alpha2b with or without ribavirin (Rib+ or Rib- group; n=7 in each group) for 24 weeks. Serum ghrelin concentrations and body weight were determined before, 2 and 24 weeks after initiation of therapy. Serum ghrelin concentrations and body weight significantly decreased 2 weeks after initiation of therapy (P=0.0008 and 0.0062, respectively), and then returned to the level before therapy. The Deltaghrelin concentration correlated with Deltabody weight after 2 weeks (r=0.726, P=0.023). Percentage reduction of serum ghrelin was significantly higher in the Rib+ group than in the Rib- group (P=0.046). Percentage reduction in body weight tended to be higher in the Rib+ group (P=0.057). IFN-alpha2b therapy causes short-term reduction of serum ghrelin and body weight, and this may occur to a greater extent with combination therapy. Reduction of serum ghrelin might contribute partly to anorexia, leading to weight loss.

Reduction of serum ghrelin concentration during interferon-alpha therapy in patients with chronic hepatitis C. Publishing Authors By Initials

H Watanabe,T Saito,T Karasawa,S Kudo,K Nakano,JI Ito,K Sugahara,K Saito,H Togashi,S Kawata,

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Reduction of serum ghrelin concentration during interferon-alpha therapy in patients with chronic hepatitis C. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 33

Page Numbers: 14-8

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ISSN: 1386-6346

DAY: 19

MONTH: 08

YEAR: 2005

Reduction of serum ghrelin concentration during interferon-alpha therapy in patients with chronic hepatitis C. Information

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LANGUAGE: eng

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AFFILIATION: Department of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.

Country: Netherlands

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MEDLINETA: Hepatol Res

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