Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen.

Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen. Abstract Text:

Yoshitaka Fujii,Masahiro Nakayama,

OBJECTIVE: Pain is a well recognised complication of propofol injection. The purpose of this study was to compare the efficacy of flurbiprofen, lidocaine and a combination of the two in reducing pain on injection of propofol. DESIGN: Prospective, randomised, double-blind, placebo-controlled study. SETTING: University hospital in Tsukuba City, Japan. PATIENTS and interventions: 120 patients, 56 males and 64 females, aged 20-66 years, scheduled for elective plastic surgery were included. Patients received intravenously either lidocaine 20mg, flurbiprofen 50mg, both, or placebo (saline) accompanied by manual venous occlusion for 2 minutes, followed by administration of propofol 2 mg/kg into a dorsal hand vein (n = 30 in each group). A blinded researcher asked each patient to evaluate the pain score (0 = none, 1 = mild, 2 = moderate, 3 = severe) during propofol injection. MAIN OUTCOME MEASURES AND RESULTS: The incidence and intensity of pain was less in patients receiving lidocaine (27%, pain score 0 [median]), flurbiprofen (43%, 0), or both (3%, 0) along with venous occlusion than in those receiving placebo (90%, 2) along with venous occlusion (p < 0.01). Combined lidocaine and flurbiprofen with venous occlusion was the most effective treatment (p < 0.05). No complications such as pain, oedema, wheal or flare response were observed at the injection sites within the first 24 hours after surgery. CONCLUSION: Combined lidocaine 20mg and flurbiprofen 50mg along with venous occlusion for 2 minutes was very effective for reducing pain on injection of propofol in patients scheduled for elective plastic surgery.

Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen. Publishing Authors By Initials

Y Fujii,M Nakayama,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical drug investigation

VOLUME: 24

Page Numbers: 749-53

Journal Abbreviation:

ISSN: 1173-2563

DAY: 25

MONTH: 05

YEAR: 2004

Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9504817

Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen.

AFFILIATION: Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan.

Country: New Zealand

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Drug Investig

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen Related Publications

• Age-related changes in BDNF protein levels in human serum: differences between autism cases and normal controls.
• Antioxidant prenylated flavonoids from propolis collected in Okinawa, Japan.
• Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori.
• Audio input device and method of controlling the same.
• Characterization of tableting using the OSDRC system.
• Deposition transfection technology using a DNA complex with a thermoresponsive cationic star polymer.
• Detection of natural killer T cells in the sinus mucosa from asthmatics with chronic sinusitis.
• Development of the wing-attached rod for acceleration of "Biotube" vascular grafts fabrication in vivo.
• Efficacy of Lignocaine plus Ketamine at Different Doses in the Prevention of Pain Due to Propofol Injection.
• Essential role of p53 in trophoblastic apoptosis induced in the developing rodent placenta by treatment with a DNA-damaging agent.
• First-principles calculations of hydrogen diffusion on rutile TiO2(110) surfaces.
• Focal intestinal perforation in extremely-low-birth-weight neonates: etiological consideration from histological findings.
• Gross total surgical removal of malignant glioma from the medulla oblongata: report of two adult cases with reference to surgical anatomy.
• HLA-DRB1*0410-restricted recognition of XAGE-1b37-48 peptide by CD4 T cells.
• Highly effective in vivo gene transfection by blocked star vector.
• Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice.
• MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation.
• Median raphe cyst with ciliated cells of the penis.
• Novel chalcones as probes for in vivo imaging of beta-amyloid plaques in Alzheimer's brains.
• Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen.
• Reduction of postoperative nausea and vomiting and analgesic requirement with dexamethasone in women undergoing general anesthesia for mastectomy.
• Revival of apoptotic cells that display early-stage dynamic membrane blebbing.
• Structure-activity relationship of chalcones and related derivatives as ligands for detecting of beta-amyloid plaques in the brain.
• The Utility of Formalin-fixed and Paraffin-embedded Tissue Blocks for Quantitative Analysis of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase mRNA Expressed by Colorectal Cancer Cells.
• The influence of object-relative visuomotor set on express saccades.
• The role of trophinin, an adhesion molecule unique to human trophoblasts, in progression of colorectal cancer.
• What are "clinical practice guidelines"?
• [A case of recurrent breast cancer with multiple liver metastases responding to combination therapy of capecitabine and MPA]
• [Coronary spastic angina and it's associated diseases]
• [Osteoporosis in the patients with rheumatoid arthritis (3) : the efficacy and the selection of the osteoporosis therapeutic drug]