Reduction in resting plasma granulysin as a marker of increased training load.

Reduction in resting plasma granulysin as a marker of increased training load. Research Abstract Details 

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Reduction in resting plasma granulysin as a marker of increased training load. Abstract Text:

Cecilia M Shing,Kazuyuki Ogawa,Xiumin Zhang,Ryoichi Nagatomi,Jonathan M Peake,Katsuhiko Suzuki,David G Jenkins,Jeff S Coombes,Cecilia M Shing,Kazuyuki Ogawa,Xiumin Zhang,Ryoichi Nagatomi,Jonathan M Peake,Katsuhiko Suzuki,David G Jenkins,Jeff S Coombes,

Granulysin is a cytolytic granule protein released by natural killer cells and activated cytotoxic T lymphocytes. The influence of exercise training on circulating granulysin concentration is unknown, as is the relationship between granulysin concentration, natural killer cell number and natural killer cell cytotoxicity. We examined changes in plasma granulysin concentration, natural killer cell number and cytotoxicity following acute exercise and different training loads. Fifteen highly trained male cyclists completed a baseline 40-km cycle time trial (TT401) followed by five weeks of normal training and a repeat time trial (TT402). The cyclists then completed four days of high intensity training followed by another time trial (TT403) on day five. Following one final week of normal training cyclists completed another time trial (TT404). Fasting venous blood was collected before and after each time trial to determine granulysin concentration, natural killer cell number and natural killer cell cytotoxicity. Granulysin concentration increased significantly after each time trial (P<0.001). Pre-exercise granulysin concentration for TT403 was significantly lower than pre-exercise concentration for TT401 (-20.3 +/- 7.5%, P<0.026), TT402 (-16.7 +/- 4.3%, P<0.003) and 7T404 (-21 +/- 4.2%, P<0.001). Circulating natural killer cell numbers also increased significantly post-exercise for each time trial (P<0.001), however there was no significant difference across TT40 (P>0.05). Exercise did not significantly alter natural killer cell cytotoxicity on a per cell basis, and there were no significant differences between the four time trials. In conclusion, plasma granulysin concentration increases following moderate duration, strenuous exercise and is decreased in response to a short-term period of intensified training.

Reduction in resting plasma granulysin as a marker of increased training load. Publishing Authors By Initials

CM Shing,K Ogawa,X Zhang,R Nagatomi,JM Peake,K Suzuki,DG Jenkins,JS Coombes,CM Shing,K Ogawa,X Zhang,R Nagatomi,JM Peake,K Suzuki,DG Jenkins,JS Coombes,

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Reduction in resting plasma granulysin as a marker of increased training load. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Exercise immunology review

VOLUME: 13

Page Numbers: 89-99

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ISSN: 1077-5552

DAY: 17

MONTH: 01

YEAR: 2007

Reduction in resting plasma granulysin as a marker of increased training load. Information

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LANGUAGE: eng

NlmUniqueID: 9505535

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Grant and Affiliation Information for Reduction in resting plasma granulysin as a marker of increased training load.

AFFILIATION: School of Human Life Sciences, University of Tasmania, Newnham, Launceston, Tasmania, 7250, Australia. Cecilia.Shing@utas.edu.au

Country: Germany

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MEDLINETA: Exerc Immunol Rev

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