Reduction in oxalate-induced renal tubular epithelial cell injury by an extract from Quercus salicina Blume/Quercus stenophylla Makino.

Reduction in oxalate-induced renal tubular epithelial cell injury by an extract from Quercus salicina Blume/Quercus stenophylla Makino. Research Abstract Details 

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Reduction in oxalate-induced renal tubular epithelial cell injury by an extract from Quercus salicina Blume/Quercus stenophylla Makino. Abstract Text:

Manabu T Moriyama,Katsuhito Miyazawa,Kumiko Noda,Michiko Oka,Mitsushi Tanaka,Koji Suzuki,

Urocalun((R)), a herbal medicine prepared from an extract of Quercus salicina Blume/Quercus stenophylla Makino (QS extract), has been clinically used for the treatment of urolithiasis in Japan since 1969. In the present study, the effects of QS extract on oxalate-induced cell injury and NADPH-induced superoxide anion (O(2) (-)) production in the injured cells were investigated. Oxalate-induced cell injury was assessed by mitochondrial reduction of 3-(4,5-dimethyl-2-thiazol)-2,5-diphenyltetrazolium bromide and leakage of lactate dehydrogenase into the extracellular fluid. When NRK-52E cells were injured by exposure to oxalate for 24 h, QS extract prevented the injury in a dose-dependent manner. In addition, QS extract suppressed the increase in NADPH-induced O(2) (-) production, or NADPH oxidase activity, in the homogenate of cells injured by oxalate exposure. These findings suggest that the reduction in oxalate-induced O(2) (-) production contributes to the cytoprotective effect of QS extract.

Reduction in oxalate-induced renal tubular epithelial cell injury by an extract from Quercus salicina Blume/Quercus stenophylla Makino. Publishing Authors By Initials

MT Moriyama,K Miyazawa,K Noda,M Oka,M Tanaka,K Suzuki,

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Reduction in oxalate-induced renal tubular epithelial cell injury by an extract from Quercus salicina Blume/Quercus stenophylla Makino. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Urological research

VOLUME: 35

Page Numbers: 295-300

Journal Abbreviation: Urol. Res.

ISSN: 0300-5623

DAY: 20

MONTH: 09

YEAR: 2007

Reduction in oxalate-induced renal tubular epithelial cell injury by an extract from Quercus salicina Blume/Quercus stenophylla Makino. Information

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LANGUAGE: eng

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AFFILIATION: Department of Urogenital Surgery, Kanazawa Medical University, Uchinada, Ishikawa, Japan, moriyama@kanazawa-med.ac.jp.

Country: Germany

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MEDLINETA: Urol Res

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