Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene.

Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene. Abstract Text:

Mikako Sakurai,Masayuki Sekiguchi,Ko Zushida,Kazuyuki Yamada,Satoshi Nagamine,Tomohiro Kabuta,Keiji Wada,Mikako Sakurai,Masayuki Sekiguchi,Ko Zushida,Kazuyuki Yamada,Satoshi Nagamine,Tomohiro Kabuta,Keiji Wada,

Overexpression of ubiquitin C-terminal hydrolase L1 (UCH-L1) in mice rescues amyloid beta-protein-induced decreases in synaptic plasticity and memory. However, the physiological role of UCH-L1 in the brain is not fully understood. In the present study, we investigated the role of UCH-L1 in the brain by utilizing gracile axonal dystrophy (gad) mice with a spontaneous deletion in the gene Uch-l1 as a loss-of-function model. Although gad mice exhibit motor paresis beginning at approximately 12 weeks of age, it is possible to analyse their brain phenotypes at a younger age when no motor paresis is evident. Maintenance of memory in a passive avoidance test and exploratory behaviour in an open field test were reduced in 6-week-old gad mice. The maintenance of theta-burst stimulation-induced long-term potentiation (LTP) of field synaptic responses from Schaffer collaterals to CA1 pyramidal cells in hippocampal slices was also impaired in gad mice. The LTP in gad mice was insensitive to actinomycin D, suggesting that a transcription-dependent component of the LTP is impaired. Phosphorylation of cyclic AMP response element binding protein (CREB) in the CA1 region of hippocampal slices from gad mice occurred earlier than in the slices from wild-type mice and was transient, suggesting that CREB phosphorylation is altered in gad mice. These results suggest that memory in passive avoidance learning, exploratory behaviour and hippocampal CA1 LTP are reduced in gad mice. We propose that UCH-L1-mediated maintenance of the temporal integrity and persistence of CREB phosphorylation underlies these impairments.

Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene. Publishing Authors By Initials

M Sakurai,M Sekiguchi,K Zushida,K Yamada,S Nagamine,T Kabuta,K Wada,M Sakurai,M Sekiguchi,K Zushida,K Yamada,S Nagamine,T Kabuta,K Wada,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The European journal of neuroscience

VOLUME: 27

Page Numbers: 691-701

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 1460-9568

DAY: 18

MONTH: Feb

YEAR: 2008

Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8918110

Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene.

AFFILIATION: Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan.

Country: France

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene Related Publications

• A comparative study of the plasma membrane permeabilization and fluidization induced by antipsychotic drugs in the rat brain.
• A method for accurate estimation of stimulating sites based on cerebral cortex structure in transcranial magnetic stimulation.
• Alpha 1-adrenoceptor agonists protect against stress-induced death of neural progenitor cells.
• Application to robot control using brain function measurement by near-infrared spectroscopy.
• Arabidopsis TRANSPARENT TESTA GLABRA2 is directly regulated by R2R3 MYB transcription factors and is involved in regulation of GLABRA2 transcription in epidermal differentiation.
• Association between trait anxiety and endothelial function observed in elderly males but not in young males.
• Can Human Isochrony be Explained by a Computational Theory?
• Chloroplast photorelocation movement mediated by phototropin family proteins in green plants.
• Collectrin, a homologue of ACE2, its transcriptional control and functional perspectives.
• Dielectric dispersion of alternating copolymers of maleic acid.
• Dietary Carnosine And Anserine Inhibits High-intensity Exercise-induced Decrease In Rat Sarcoplasmic Reticulum Ca2+ -handling: 2073: Board #143 May 31 3:30 PM 5:00 PM.
• Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues.
• Effect of beta-lactotensin on acute stress and fear memory.
• Effects of heat stress on filamentous actin and prestin of outer hair cells in mice.
• Estimation of force motor command for NIRS-based BMI.
• Functional analysis of the epidermal-specific MYB genes CAPRICE and WEREWOLF in Arabidopsis.
• Glycogen synthase kinase-3beta: homologous regulation of cell surface insulin receptor level via controlling insulin receptor mRNA stability in adrenal chromaffin cells.
• Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening.
• Life style-related diseases of the digestive system: from molecular mechanisms to therapeutic strategies: preface.
• Movement time planning in human movement with via-points.
• New method for simultaneous measurement of frequency spectra of complex dielectric constants of polyelectrolyte solutions.
• Preface.
• Remediation of Pb-contaminated soils by washing with hydrochloric acid and subsequent immobilization with calcite and allophanic soil.
• Sodium D(2) resonance radiation in single-pass sum-frequency generation with actively mode-locked Nd:YAG lasers.
• The association between anger-related personality trait and cardiac autonomic response abnormalities in elderly subjects.
• Topological and chronological features of the impairment of glucose metabolism induced by 1-methyl-4-phenylpyridinium ion (MPP(+)) in rat brain slices.
• [Anti-tuberculosis chemotherapy]
• [Diastolic heart failure]
• [New direction of medical malpractice dispute resolution]
• [Teaching surveillance to workers' health in nursing courses]