Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources.

Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Research Abstract Details 

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Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Abstract Text:

Carolyn M Kercsmar,Dorr G Dearborn,Mark Schluchter,Lintong Xue,H Lester Kirchner,John Sobolewski,Stuart J Greenberg,Stephen J Vesper,Terry Allan,

OBJECTIVE: Home dampness and the presence of mold and allergens have been associated with asthma morbidity. We examined changes in asthma morbidity in children as a result of home remediation aimed at moisture sources. DESIGN: In this prospective, randomized controlled trial, symptomatic, asthmatic children (n = 62), 2-17 years of age, living in a home with indoor mold, received an asthma intervention including an action plan, education, and individualized problem solving. The remediation group also received household repairs, including reduction of water infiltration, removal of water-damaged building materials, and heating/ventilation/air-conditioning alterations. The control group received only home cleaning information. We measured children's total and allergen-specific serum immuno-globulin E, peripheral blood eosinophil counts, and urinary cotinine. Environmental dust samples were analyzed for dust mite, cockroach, rodent urinary protein, endotoxin, and fungi. The follow-up period was 1 year. RESULTS: Children in both groups showed improvement in asthma symptomatic days during the preremediation portion of the study. The remediation group had a significant decrease in symptom days (p = 0.003, as randomized; p = 0.004, intent to treat) after remodeling, whereas these parameters in the control group did not significantly change. In the postremediation period, the remediation group had a lower rate of exacerbations compared with control asthmatics (as treated: 1 of 29 vs. 11 of 33, respectively, p = 0. 003; intent to treat: 28.1% and 10.0%, respectively, p = 0.11). CONCLUSION: Construction remediation aimed at the root cause of moisture sources and combined with a medical/behavioral intervention significantly reduces symptom days and health care use for asthmatic children who live in homes with a documented mold problem.

Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Publishing Authors By Initials

CM Kercsmar,DG Dearborn,M Schluchter,L Xue,HL Kirchner,J Sobolewski,SJ Greenberg,SJ Vesper,T Allan,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research

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Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Environmental health perspectives

VOLUME: 114

Page Numbers: 1574-80

Journal Abbreviation: Environ. Health Perspect.

ISSN: 0091-6765

DAY: 3

MONTH: Oct

YEAR: 2006

Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 330411

Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Keywords Mesh Terms:

KEYWORDS: Prospective Studies

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Information

Substance Name: Dust

Registry Number: 0

Grant and Affiliation Information for Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources.

AFFILIATION: Case Western Reserve University, Department of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, Ohio 44106, USA. carolyn.kercsmar@uhhs.com

Country: United States

AGENCY: United States NCRR

GRANT: M01 RR00080

ACRONYM: RR

MEDLINETA: Environ Health Perspect

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