Reducing the dose of depot neuroleptics in stable schizophrenia.

Reducing the dose of depot neuroleptics in stable schizophrenia. Research Abstract Details 

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Reducing the dose of depot neuroleptics in stable schizophrenia. Abstract Text:

In order to determine the safety of reducing maintenance neuroleptic dose in long-term ambulatory schizophrenia, a step-wise depot reduction study was carried out on patients over a six month period. Doses were reduced by 1/8 of original approximately every two months for a total of three reductions. At the end of dose reduction and at six month follow-up, relapse rate was calculated. Relapse in this study was defined as the clinical decision to either increase neuroleptic dose or to hospitalize. Approximately 50% of the patients relapsed. There was no association with life events as measured by the Paykel scale. Where relapse occurred, it was usually seen subsequent to the second dose reduction. Patients who survived dose reduction had been maintained for a significantly longer period on depot neuroleptics and tended to suffer from a form of schizophrenia which required the co-administration of antidepressants. The findings show that, for a population on long-term depot medication, the risk of symptom exacerbation after gradual step-wise neuroleptic reduction is 50%. The results help to delineate which patients will fall into that 50%.

Reducing the dose of depot neuroleptics in stable schizophrenia. Publishing Authors By Initials

For similar behavioral disciplines and activities: schizophrenic psychology research abstracts see: behavioral disciplines and activities: schizophrenic psychology research

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Reducing the dose of depot neuroleptics in stable schizophrenia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of psychiatry & neuroscience : JPN

VOLUME: 19

Page Numbers: 278-81

Journal Abbreviation: J Psychiatry Neurosci

ISSN: 1180-4882

DAY: 6

MONTH: Jul

YEAR: 1994

Reducing the dose of depot neuroleptics in stable schizophrenia. Information

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LANGUAGE: eng

NlmUniqueID: 9107859

Reducing the dose of depot neuroleptics in stable schizophrenia. Keywords Mesh Terms:

KEYWORDS: Schizophrenic Psychology

MESH TERMS: rehabilitation

Chemical & Substance for Abstract: Reducing the dose of depot neuroleptics in stable schizophrenia. Information

Substance Name: Antipsychotic Agents

Registry Number: 0

Grant and Affiliation Information for Reducing the dose of depot neuroleptics in stable schizophrenia.

AFFILIATION: Wellborn Baptist Hospital, Evansville, Indiana.

Country: CANADA

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MEDLINETA: J Psychiatry Neurosci

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