Reducing interscanner variability of activation in a multicenter fMRI study: controlling for signal-to-fluctuation-noise-ratio (SFNR) differences.

Reducing interscanner variability of activation in a multicenter fMRI study: controlling for signal-to-fluctuation-noise-ratio (SFNR) differences. Research Abstract Details 

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Reducing interscanner variability of activation in a multicenter fMRI study: controlling for signal-to-fluctuation-noise-ratio (SFNR) differences. Abstract Text:

Lee Friedman,Gary H Glover, ,

Variation in scanner performance will lead to variation in activation patterns in multicenter fMRI studies. The purpose of this investigation was to evaluate the effect of statistically covarying for scanner differences in signal-to-fluctuation-noise-ratio (SFNR) on reducing scanner differences in activation effect size as part of a multicenter fMRI project (FIRST BIRN). For SFNR, "signal" is typically the mean intensity over time and "fluctuation noise" is the temporal standard deviation. Five subjects were sent to 9 centers (10 scanners) and scanned on two consecutive days using a sensorimotor fMRI protocol. High-field (4 T and 3 T) and low-field (1.5 T) scanners from three vendors (GE, Siemens and Picker) were included. The effect size for the detection of neural activation during a sensorimotor task was evaluated as the percent of temporal variance accounted for by our model (percent of variance accounted for, or PVAF). Marked scanner effects were noted for both PVAF as well as SFNR. After covariate adjustment with one of several measures of SFNR, there were dramatic reductions in scanner-to-scanner variations in activation effect size. Variance components analyses revealed 75%-81% reductions in variance due to scanner with this method. Thus, controlling for scanner variation in SFNR may be an effective method to homogenize activation effect sizes in multicenter studies.

Reducing interscanner variability of activation in a multicenter fMRI study: controlling for signal-to-fluctuation-noise-ratio (SFNR) differences. Publishing Authors By Initials

L Friedman,GH Glover, ,

For similar investigative techniques: epidemiologic methods: epidemiologic research design: reproducibility of results research abstracts see: investigative techniques: epidemiologic methods: epidemiologic research design: reproducibility of results research

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Reducing interscanner variability of activation in a multicenter fMRI study: controlling for signal-to-fluctuation-noise-ratio (SFNR) differences. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: NeuroImage

VOLUME: 33

Page Numbers: 471-81

Journal Abbreviation: Neuroimage

ISSN: 1053-8119

DAY: 6

MONTH: 09

YEAR: 2006

Reducing interscanner variability of activation in a multicenter fMRI study: controlling for signal-to-fluctuation-noise-ratio (SFNR) differences. Information

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LANGUAGE: eng

NlmUniqueID: 9215515

Reducing interscanner variability of activation in a multicenter fMRI study: controlling for signal-to-fluctuation-noise-ratio (SFNR) differences. Keywords Mesh Terms:

KEYWORDS: Reproducibility of Results

MESH TERMS: anatomy & histology

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Grant and Affiliation Information for Reducing interscanner variability of activation in a multicenter fMRI study: controlling for signal-to-fluctuation-noise-ratio (SFNR) differences.

AFFILIATION: Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, CA 92617, USA. lfriedman10@comcast.net

Country: United States

AGENCY: United States NCRR

GRANT: 1 U24 RR021992

ACRONYM: RR

MEDLINETA: Neuroimage

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