Reduced thymic size and numbers of splenic CD4+ and CD8+ cells in artificially reared mouse pups.

Reduced thymic size and numbers of splenic CD4+ and CD8+ cells in artificially reared mouse pups. Research Abstract Details 

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Reduced thymic size and numbers of splenic CD4+ and CD8+ cells in artificially reared mouse pups. Abstract Text:

Masako Yajima,Junji Hoshiba,Masaki Terahara,Takaji Yajima,Masako Yajima,Junji Hoshiba,Masaki Terahara,Takaji Yajima,

The effect of early nutrition on the development of the immune tissue and T cells of mouse pups was examined. Newborn mice were divided into three experimental groups: mother-reared (MR) pups, pups that were fed on a milk substitute from the first day (AR-0), and the third day (AR-2), using a hand-feeding system. The average thymic size of the AR-2 pups was respectively significantly larger and smaller than that of the AR-0 and MR pups. In contrast, the splenic sizes of the AR-0 and AR-2 pups were greater than that of the MR pups. The numbers of CD4+CD8- and CD4-CD8+ cells in the spleen of the MR pups were significantly higher than those in the AR-0 pups. These results indicate that early nutrition affected the sizes of the thymus and spleen and the composition of CD4+CD8- or CD4-CD8+ T cells in the spleen.

Reduced thymic size and numbers of splenic CD4+ and CD8+ cells in artificially reared mouse pups. Publishing Authors By Initials

M Yajima,J Hoshiba,M Terahara,T Yajima,M Yajima,J Hoshiba,M Terahara,T Yajima,

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Reduced thymic size and numbers of splenic CD4+ and CD8+ cells in artificially reared mouse pups. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioscience, biotechnology, and biochemistry

VOLUME: 71

Page Numbers: 2420-7

Journal Abbreviation: Biosci. Biotechnol. Biochem.

ISSN: 0916-8451

DAY: 7

MONTH: 10

YEAR: 2007

Reduced thymic size and numbers of splenic CD4+ and CD8+ cells in artificially reared mouse pups. Information

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LANGUAGE: eng

NlmUniqueID: 9205717

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AFFILIATION: Department of Lactic Acid Bacteria, Food Science Institute, Division of Research and Development, Meiji Dairies Corporation, Japan. yajimama@cris.hokudai.ac.jp

Country: Japan

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MEDLINETA: Biosci Biotechnol Biochem

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