Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn.

Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn. Research Abstract Details 

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Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn. Abstract Text:

A Aria Tzika,Dionyssios Mintzopoulos,Katie Padfield,Julie Wilhelmy,Michael N Mindrinos,Hongue Yu,Haihui Cao,Qunhao Zhang,Loukas G Astrakas,Jiangwen Zhang,Yong-Ming Yu,Laurence G Rahme,Ronald G Tompkins,A Aria Tzika,Dionyssios Mintzopoulos,Katie Padfield,Julie Wilhelmy,Michael N Mindrinos,Hongue Yu,Haihui Cao,Qunhao Zhang,Loukas G Astrakas,Jiangwen Zhang,Yong-Ming Yu,Laurence G Rahme,Ronald G Tompkins,

Using a mouse model of burn trauma, we tested the hypothesis that severe burn trauma corresponding to 30% of total body surface area (TBSA) causes reduction in adenosine triphosphate (ATP) synthesis in distal skeletal muscle. We employed in vivo 31P nuclear magnetic resonance (NMR) in intact mice to assess the rate of ATP synthesis, and characterized the concomitant gene expression patterns in skeletal muscle in burned (30% TBSA) versus control mice. Our NMR results showed a significantly reduced rate of ATP synthesis and were complemented by genomic results showing downregulation of the ATP synthase mitochondrial F1F0 complex and PGC-1beta gene expression. Our findings suggest that inflammation and muscle atrophy in burns are due to a reduced ATP synthesis rate that may be regulated upstream by PGC-1beta. These findings implicate mitochondrial dysfunction in distal skeletal muscle following burn injury. That PGC-1beta is a highly inducible factor in most tissues and responds to common calcium and cyclic adenosine monophosphate (cAMP) signaling pathways strongly suggests that it may be possible to develop drugs that can induce PGC-1beta.

Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn. Publishing Authors By Initials

AA Tzika,D Mintzopoulos,K Padfield,J Wilhelmy,MN Mindrinos,H Yu,H Cao,Q Zhang,LG Astrakas,J Zhang,YM Yu,LG Rahme,RG Tompkins,AA Tzika,D Mintzopoulos,K Padfield,J Wilhelmy,MN Mindrinos,H Yu,H Cao,Q Zhang,LG Astrakas,J Zhang,YM Yu,LG Rahme,RG Tompkins,

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Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of molecular medicine

VOLUME: 21

Page Numbers: 201-8

Journal Abbreviation: Int. J. Mol. Med.

ISSN: 1107-3756

DAY: 21

MONTH: Feb

YEAR: 2008

Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn. Information

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LANGUAGE: eng

NlmUniqueID: 9810955

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Grant and Affiliation Information for Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn.

AFFILIATION: NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. atzika@partners.org.

Country: Greece

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MEDLINETA: Int J Mol Med

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