Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice.

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. Abstract Text:

Manyu Li,Della Yee,Terry R Magnuson,Oliver Smithies,Kathleen M Caron,

Adrenomedullin (AM) is a multifunctional peptide vasodilator that is essential for life. Plasma AM expression dramatically increases during pregnancy, and alterations in its levels are associated with complications of pregnancy including fetal growth restriction (FGR) and preeclampsia. Using AM+/- female mice with genetically reduced AM expression, we demonstrate that fetal growth and placental development are seriously compromised by this modest decrease in expression. AM+/- female mice had reduced fertility characterized by FGR. The incidence of FGR was also influenced by the genotype of the embryo, since AM-/- embryos were more often affected than either AM+/- or AM+/+ embryos. We demonstrate that fetal trophoblast cells and the maternal uterine wall have coordinated and localized increases in AM gene expression at the time of implantation. Placentas from growth-restricted embryos showed defects in trophoblast cell invasion, similar to defects that underlie human preeclampsia and placenta accreta. Our data provide a genetic in vivo model to implicate both maternal and, to a lesser extent, embryonic levels of AM in the processes of implantation, placentation, and subsequent fetal growth. This study provides the first genetic evidence to our knowledge to suggest that a modest reduction in human AM expression during pregnancy may have an unfavorable impact on reproduction.

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. Publishing Authors By Initials

M Li,D Yee,TR Magnuson,O Smithies,KM Caron,

For similar urogenital system: genitalia: genitalia, female: uterus research abstracts see: urogenital system: genitalia: genitalia, female: uterus research

PUBMED ID PMID:

MEDLINE DATE:

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of clinical investigation

VOLUME: 116

Page Numbers: 2653-62

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 14

MONTH: 09

YEAR: 2006

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7802877

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. Keywords Mesh Terms:

KEYWORDS: Uterus

MESH TERMS: metabolism

Chemical & Substance for Abstract: Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. Information

Substance Name: Adrenomedullin

Registry Number: 148498-78-6

Grant and Affiliation Information for Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice.

AFFILIATION: Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS031768

ACRONYM: NS

MEDLINETA: J Clin Invest

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice Related Publications

• A beta-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior.
• Acute bacterial prostatitis: heterogeneity in diagnostic criteria and management. Retrospective multicentric analysis of 371 patients diagnosed with acute prostatitis.
• Adrenomedullin signaling is necessary for murine lymphatic vascular development.
• Allergy to multiple local anesthetics.
• Building a collaborative hematology/oncology advanced nursing practice: part I.
• Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction.
• Defective efficacy of retinoic Acid treatment in patients with metastatic thyroid carcinoma.
• Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin.
• Lack of systemic absorption of lidocaine from 5% patches placed on horses.
• Long-term (up to 18 years) effects on GH/IGF-1 hypersecretion and tumour size of primary somatostatin analogue (SSTa) therapy in patients with GH-secreting pituitary adenoma responsive to SSTa.
• MR cholangiopancreatography versus endoscopic sonography in suspected common bile duct lithiasis: a prospective, comparative study.
• Mice heterozygous for adrenomedullin exhibit a more extreme inflammatory response to endotoxin-induced septic shock.
• Neuroblastoma: biology, prognosis, and treatment.
• Palaeontology. Ancient worms in armour.
• Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice.
• Performance of the urine leukocyte esterase and nitrite dipstick test for the diagnosis of acute prostatitis.
• Phase transformation and segregation to lattice defects in ni-base superalloys.
• Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age.
• Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling.
• Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice.
• Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo.
• Role of GSK3beta in behavioral abnormalities induced by serotonin deficiency.
• [Approach to male alcoholism in France. Clinical and therapeutic aspects]
• [Dyspnea in orthopedics (author's transl)]
• [Early mobilization after reduction and retention by pin of fractures of the posterior tarsus]
• [Indications for the orthopedic management of children with cerebral palsy]
• [Management of fungal urinary tract infections]
• [Surgical treatment of discal hernia]
• [Therapeutic indications in scoliosis occurring during growth]
• [Value of noninvasive cardiac function tests in the chronic phase of myocardial infarct]