Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda.

Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda. Research Abstract Details 

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Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda. Abstract Text:

Ruby H N Nguyen,Stephen J Gange,Fred Wabwire-Mangen,Nelson K Sewankambo,David Serwadda,Maria J Wawer,Thomas C Quinn,Ronald H Gray,

We assessed whether HIV-1 viral load affects the likelihood of live birth among HIV-positive women in a nested case-control study of HIV-positive women from a community cohort in Rakai District, Uganda. Cases were women who had a live birth (n = 270), and controls were sexually active women who did not use contraception and did not become pregnant during follow-up (n = 263). In women with a live birth and non-pregnant controls, median HIV viral loads were 4.12 log(10) copies/mL and 4.41 log(10) copies/mL, respectively (P = 0.001). A non-linear association was observed, and a segmented linear regression with spline knot at 4.5 log(10) copies/mL was fit. We observed a decline in the log (adjusted odds ratio [adj. OR])= -0.08 (95% confidence interval [CI]: -0.36, 0.20) between 3.0 and 4.49 log(10) viral load and -0.92 (95% CI: -1.21, -0.63) between 4.5 and 6.5 log(10) viral load. The two reductions differed significantly from one another (P < 0.001). Each increase in log(10) viral load after 4.5 log(10) resulted in an adj. OR of live birth which was 12% of the previous viral load category. Our data suggest that there may be considerable differences in the ability to produce a live birth among HIV-positive women with high viral loads.

Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda. Publishing Authors By Initials

RH Nguyen,SJ Gange,F Wabwire-Mangen,NK Sewankambo,D Serwadda,MJ Wawer,TC Quinn,RH Gray,

For similar investigative techniques: clinical laboratory techniques: microbiological techniques: viral load research abstracts see: investigative techniques: clinical laboratory techniques: microbiological techniques: viral load research

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Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: International journal of STD & AIDS

VOLUME: 17

Page Numbers: 842-6

Journal Abbreviation:

ISSN: 0956-4624

DAY: 3

MONTH: Dec

YEAR: 2006

Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda. Information

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LANGUAGE: eng

NlmUniqueID: 9007917

Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda. Keywords Mesh Terms:

KEYWORDS: Viral Load

MESH TERMS: epidemiology

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Grant and Affiliation Information for Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda.

AFFILIATION: Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC 27709, USA. nguyen5@niehs.nih.gov

Country: England

AGENCY: United States NICHD

GRANT: R01HD38883

ACRONYM: HD

MEDLINETA: Int J STD AIDS

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