Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes.

Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes. Abstract Text:

Liliana N Berti-Mattera,Cheryl E Gariepy,Rebecca M Burke,Alison K Hall,

Diabetic neuropathy is one of the major complications of diabetes mellitus. Small nerve fibers degenerate early in the disease, leading to symptoms ranging from hyperalgesia to loss of pain and temperature sensation. However, the cellular and molecular mechanisms responsible for abnormal pain perception in diabetes have not been identified. Both type-A and type-B endothelin receptors (ETAR and ETBR, respectively) are present in sensory nerves and appear to regulate neuropathic and inflammatory pain. In this study, we compared the expression of endothelin receptors and nociceptive responses in normal and experimentally diabetic rats. Diabetic animals exhibited both an increase in the withdrawal responses to high threshold stimuli (mechanical hyperalgesia) and to light touch stimuli (tactile allodynia). Immunohistochemical and Western blot analysis revealed that diabetic rats have significantly reduced expression of ETBR in sciatic nerves, while no changes were observed in dorsal root ganglia (DRG). In contrast, the expression of ETAR in either sciatic nerves or DRG of diabetic rats was not altered. Importantly, ETBR-deficient transgenic rats showed alterations in pain perception similar to those observed in diabetic rats. These results suggest that changes in the expression of ETBR in peripheral nerve may contribute to the development of mechanical hyperalgesia and tactile allodynia in chronic diabetes.

Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes. Publishing Authors By Initials

LN Berti-Mattera,CE Gariepy,RM Burke,AK Hall,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental neurology

VOLUME: 201

Page Numbers: 399-406

Journal Abbreviation:

ISSN: 0014-4886

DAY: 27

MONTH: 06

YEAR: 2006

Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370712

Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes.

AFFILIATION: Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106-7288, USA. lnb@cwru.edu

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Exp Neurol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes Related Publications

• A comparison of Ki67 immunostaining and nucleolar organiser region staining in non-Hodgkin's lymphoma. P. A. Hall, J. Crocker, A. Watts, A. G. Stansfeld. Histopathology 1988; 12; 373-381 &.
• A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases.
• A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways.
• A summary of recommendations for the management of opioid dependence: the quality assurance in the treatment of drug dependence project.
• AQP0-LTR of the Cat Fr mouse alters water permeability and calcium regulation of wild type AQP0.
• Activation of G1 progression, JNK mitogen-activated protein kinase, and actin filament assembly by the exchange factor FGD1.
• Activin and bone morphogenetic proteins induce calcitonin gene-related peptide in embryonic sensory neurons in vitro.
• Editorial.
• Effect of cartilage oligomeric matrix protein on mesenchymal chondrogenesis in vitro.
• Effect of nutrition on the LH response to calf removal and GnRH.
• Efficient chondrogenic differentiation of mesenchymal cells in micromass culture by retroviral gene transfer of BMP-2.
• Gene expression profiling following BMP-2 induction of mesenchymal chondrogenesis in vitro.
• In-situ hydration studies using multi-angle energy-dispersive diffraction.
• International studies in dementia with particular emphasis on populations of African origin.
• Investigations of the incidence of bovine trichomoniasis in nevada and of the efficacy of immunizing cattle with vaccines containing Tritrichomonas foetus.
• Is ultrasound useful for evaluating paediatric inflammatory neck masses?
• Laparoscopic transfer of ovine and cervine embryos using the transpic technique.
• Nonword repetition skills in young children who do and do not stutter.
• Oxygen cathode measurements and radiation response in tumour-bearing mice treated with misonidazole.
• Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade.
• Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16.
• Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes.
• Spontaneous formation of annular structures observed in molecular dynamics simulations of polyglutamine peptides.
• Systems approaches to biological rhythms in Drosophila.
• The effectiveness of methadone maintenance treatment: an overview.
• The use of derivative and least-squares methods to analyse a polypharmaceutical product by UV spectrophotometry.
• Validation analysis of informant's ratings of cognitive function in African Americans and Nigerians.
• Viral Load and Neuropsychological Functioning in HIV Seropositive Individuals:A Preliminary Descriptive Study.
• [In Process Citation]
• [In Process Citation]