Reduced expression of apaf-1 in colorectal adenocarcinoma correlates with tumor progression and aggressive phenotype.

Reduced expression of apaf-1 in colorectal adenocarcinoma correlates with tumor progression and aggressive phenotype. Research Abstract Details 

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Reduced expression of apaf-1 in colorectal adenocarcinoma correlates with tumor progression and aggressive phenotype. Abstract Text:

Seung Sam Paik,Ki-Seok Jang,Young Soo Song,Si-Hyong Jang,Kyueng-Whan Min,Hong Xiu Han,Woong Na,Kang Hong Lee,Dongho Choi,Se Jin Jang,Seung Sam Paik,Ki-Seok Jang,Young Soo Song,Si-Hyong Jang,Kyueng-Whan Min,Hong Xiu Han,Woong Na,Kang Hong Lee,Dongho Choi,Se Jin Jang,Seung Sam Paik,Ki-Seok Jang,Young Soo Song,Si-Hyong Jang,Kyueng-Whan Min,Hong Xiu Han,Woong Na,Kang Hong Lee,Dongho Choi,Se Jin Jang,

BACKGROUND: Apoptotic protease activating factor-1 (Apaf-1) is one of the key regulators in the mitochondrial apoptotic pathway, and the loss of Apaf-1 leads to cellular resistance against the apoptotic signals. We investigated the expression of Apaf-1 in colorectal tissues corresponding to the multistep carcinogenesis model to determine correlations between the clinicopathologic characteristics and the expression of this molecule and to evaluate the role of Apaf-1 in the development and progression of colorectal adenocarcinoma. METHODS: Immunohistochemistry for Apaf-1 was performed on the tissue microarray of 38 normal mucosal tissues, 46 adenomatous polyps, 529 colorectal adenocarcinomas, and 76 metastatic tumors. RESULTS: Normal colonic mucosa tissues and adenomas were positive for Apaf-1 with no exceptions (100%). However, in colorectal adenocarcinomas, 119 of 529 cases (22.5%) were positive and 410 cases (77.5%) were negative. Moreover, 67 of 76 metastatic cases (88.2 %) were negative and only nine cases (11.8%) were positive for Apaf-1 expression. In the analyses between Apaf-1 expression and clinicopathologic parameters, reduced expression of Apaf-1 correlated with left colon location (p < 0.001), deeper tumor invasion (p < 0.001), frequent lymph node metastasis ( p= 0.021), higher American Joint Committee on Cancer (AJCC) and Dukes' stage (p = 0.02 and p = 0.001, respectively) and poorer differentiation (p < 0.001). The patient survival was significantly associated with age, histological grade, AJCC stage, and lymphovascular invasion, but not Apaf-1 expression (p = 0.478). CONCLUSIONS: The results suggest that the loss of Apaf-1 expression is a relatively frequent late event and the loss of Apaf-1 expression may play an important role in tumorigenesis and tumor progression in colorectal adenocarcinoma.

Reduced expression of apaf-1 in colorectal adenocarcinoma correlates with tumor progression and aggressive phenotype. Publishing Authors By Initials

SS Paik,KS Jang,YS Song,SH Jang,KW Min,HX Han,W Na,KH Lee,D Choi,SJ Jang,SS Paik,KS Jang,YS Song,SH Jang,KW Min,HX Han,W Na,KH Lee,D Choi,SJ Jang,SS Paik,KS Jang,YS Song,SH Jang,KW Min,HX Han,W Na,KH Lee,D Choi,SJ Jang,

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Reduced expression of apaf-1 in colorectal adenocarcinoma correlates with tumor progression and aggressive phenotype. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of surgical oncology

VOLUME: 14

Page Numbers: 3453-9

Journal Abbreviation: Ann. Surg. Oncol.

ISSN: 1068-9265

DAY: 20

MONTH: 09

YEAR: 2007

Reduced expression of apaf-1 in colorectal adenocarcinoma correlates with tumor progression and aggressive phenotype. Information

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LANGUAGE: eng

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AFFILIATION: Departments of Pathology, College of Medicine, Hanyang University, Seoul, Korea.

Country: United States

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MEDLINETA: Ann Surg Oncol

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