Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients.

Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Abstract Text:

Cynthia Shannon Weickert,Debora A Rothmond,Thomas M Hyde,Joel E Kleinman,Richard E Straub,Cynthia Shannon Weickert,Debora A Rothmond,Thomas M Hyde,Joel E Kleinman,Richard E Straub,Cynthia Shannon Weickert,Debora A Rothmond,Thomas M Hyde,Joel E Kleinman,Richard E Straub,

Genetic and molecular studies indicate that dysbindin-1 plays a role in the pathophysiology of schizophrenia. We examined dysbindin-1 mRNA in the hippocampal formation of patients with schizophrenia and found reduced expression in dentate granule and polymorph cells and in hippocampal field CA3, but not in CA1. Furthermore, there were positive correlations between dysbindin-1 mRNA and expression of synaptic markers known to be reduced in schizophrenia. Our results indicate that previously reported dysbindin-1 protein reductions may be due in part to decreased dysbindin-1 mRNA and that reduced dysbindin-1 may contribute to hippocampal formation synaptic pathology in schizophrenia.

Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Publishing Authors By Initials

CS Weickert,DA Rothmond,TM Hyde,JE Kleinman,RE Straub,CS Weickert,DA Rothmond,TM Hyde,JE Kleinman,RE Straub,CS Weickert,DA Rothmond,TM Hyde,JE Kleinman,RE Straub,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Schizophrenia research

VOLUME: 98

Page Numbers: 105-10

Journal Abbreviation: Schizophr. Res.

ISSN: 0920-9964

DAY: 24

MONTH: 10

YEAR: 2007

Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8804207

Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients.

AFFILIATION: MiNDS Unit of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA; Schizophrenia Research Institute, Prince of Wales Medical Research Institute, University of New South Wales, Australia and IRP, NIMH, NIH, Bethesda, MD 20892, USA.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Schizophr Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Reduced DTNBP1 dysbindin-1 mRNA in the hippocampal formation of schizophrenia patients Related Publications

• B-cell involvement in the pathogenesis of RA-is there a contribution of the sympathetic nervous system?
• Circadian rhythms in arthritis: Hormonal effects on the immune/inflammatory reaction.
• Commentary 2 on "Physiological responses to rock climbing in young climbers".
• Comparison of interferon production in cattle after intranasal infection with parainfluenza-3 live vaccine and avirulent IBR/IPV-herpesvirus.
• Detection of precipitating antibodies and identification of bovine leukemia virus antigens by micro counter-current immunoelectrophoresis.
• Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization.
• Immunofluorescence test for bovine leukosis-associated complement-fixing antibodies.
• Increased chromogranin a levels indicate sympathetic hyperactivity in patients with rheumatoid arthritis and systemic lupus erythematosus.
• Lack of dehydroepiandrosterone in type I and II hereditary angioedema and role of danazol in steroid hormone conversion.
• Lower density of synovial nerve fibres positive for calcitonin gene-related peptide relative to substance P in rheumatoid arthritis but not in osteoarthritis.
• Monte Carlo simulations of polyalanine using a reduced model and statistics-based interaction potentials.
• Myoglobinuria in boys with Duchenne muscular dystrophy on corticosteroid therapy.
• Occupational therapy in fracture treatment.
• Pathological observations on tuberculosis of Indonesians in Batavia in 1946.
• Pericardial celomic cyst; report of a case.
• Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients.
• Retention with a new type of retainer designed to improve the retentive qualities of the retainer.
• Stress as a risk factor in the pathogenesis of rheumatoid arthritis.
• Undergraduate sanitary engineering training in the United States.
• Vibrational energy relaxation of isotopically labeled amide I modes in cytochrome c: theoretical investigation of vibrational energy relaxation rates and pathways.
• [Comparison of various serological methods for the demonstration of Maedi/Visna virus antibodies]
• [MD-NET--muscular dystrophy network]
• [Not Available.]
• [Not Available.]
• [Nursing process. Nursing of a patient with Crohn's enterocolitis in the terminal stage "...it is more than just care, it is human solicitude"]
• [On the importance of persisting lymphocytosis for inferences concerning the etiology of bovine lymphosarcoma]
• [Studies on the validity of the leukosis key for breeds other than Holstein-Friesian cattle)]
• [The serum gamma-globulin picture in leucosis of cattle and sheep]
• [What is ensured in anticoagulant therapy?]
• mu-Acetylide and mu-alkenylidene ligands in "click" triazole syntheses.