Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids.

Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids. Research Abstract Details 

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Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids. Abstract Text:

Beth Levant,Jeffery D Radel,Susan E Carlson,

BACKGROUND: Low levels of n-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA, 22:6n3), are implicated in postpartum depression. METHODS: The effects of pregnancy and lactation on brain phospholipid fatty acid content were determined in female rats fed diets containing sufficient (control) or negligible (deficient) alpha-linolenic acid (18:3n-3), the dietary precursor of DHA, beginning at conception. Female virgins, fed the diets for 6 weeks, served as control animals. Whole brain total phospholipid composition was determined at weaning by GC. RESULTS: Brain DHA content of postpartum dams fed the deficient diet was decreased by 21% compared with age-matched virgin control animals, with a reciprocal increase in docosapentaenoic acid (22:5n6) to 243%. CONCLUSIONS: Under dietary conditions supplying inadequate n-3 PUFAs, maternal brain DHA content can be reduced after a single reproductive cycle. This depletion may affect neuronal function and thus the sensitivity of the postpartum organism to stress.

Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids. Publishing Authors By Initials

B Levant,JD Radel,SE Carlson,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, long-evans research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, long-evans research

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Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological psychiatry

VOLUME: 60

Page Numbers: 987-90

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 24

MONTH: 02

YEAR: 2006

Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids. Keywords Mesh Terms:

KEYWORDS: Rats, Long-Evans

MESH TERMS: metabolism

Chemical & Substance for Abstract: Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids. Information

Substance Name: Docosahexaenoic Acids

Registry Number: 25167-62-8

Grant and Affiliation Information for Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids.

AFFILIATION: Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. blevant@kumc.edu

Country: United States

AGENCY: United States NIMH

GRANT: MH071599

ACRONYM: MH

MEDLINETA: Biol Psychiatry

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