Reduced {alpha}4 1 Integrin/VCAM-1 Interactions Lead to Impaired Pre-B Cell Repopulation in Alpha 1,6-Fucosyltransferase Deficient Mice.

Reduced {alpha}4 1 Integrin/VCAM-1 Interactions Lead to Impaired Pre-B Cell Repopulation in Alpha 1,6-Fucosyltransferase Deficient Mice. Research Abstract Details 

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Reduced {alpha}4 1 Integrin/VCAM-1 Interactions Lead to Impaired Pre-B Cell Repopulation in Alpha 1,6-Fucosyltransferase Deficient Mice. Abstract Text:

Wenzhe Li,Katsuhiko Ishihara,Takafumi Yokota,Takatoshi Nakagawa,Nobuto Koyama,Jinhua Jin,Yoko Mizuno-Horikawa,Xiangchun Wang,Eiji Miyoshi,Naoyuki Taniguchi,Akihiro Kondo,Wenzhe Li,Katsuhiko Ishihara,Takafumi Yokota,Takatoshi Nakagawa,Nobuto Koyama,Jinhua Jin,Yoko Mizuno-Horikawa,Xiangchun Wang,Eiji Miyoshi,Naoyuki Taniguchi,Akihiro Kondo,Wenzhe Li,Katsuhiko Ishihara,Takafumi Yokota,Takatoshi Nakagawa,Nobuto Koyama,Jinhua Jin,Yoko Mizuno-Horikawa,Xiangchun Wang,Eiji Miyoshi,Naoyuki Taniguchi,Akihiro Kondo,

Mice with a targeted gene disruption of Fut8 (Fut8(-/-)) showed an abnormality in the transition from pro-B cell to pre-B cell, reduced peripheral B cells, and a decreased immunoglobulin production. Alpha 1,6-fucosyltransferase (FUT8) is responsible for the alpha 1,6 core fucosylation of N-glycans, which could modify the functions of glycoproteins. The loss of a core fucose in both very late antigen 4 (VLA-4, alpha4beta1 integrin) and vascular cell adhesion molecule 1 (VCAM-1) led to a decreased binding between pre-B cells and stromal cells, which impaired pre-B cells generation in Fut8(-/-) mice. Moreover, the B lineage genes, such as CD79a, CD79b, Ebf1, and Tcfe2a, were downregulated in Fut8(-/-) pre-B cells. Indeed, the frequency of preBCR(+)CD79b(low) cells in bone marrow pre-B cells in Fut8(-/-) was much lower than that in Fut8(+/+) cells. These results reveal a new role of core fucosylated N-glycans in mediating early B cell development and functions.

Reduced {alpha}4 1 Integrin/VCAM-1 Interactions Lead to Impaired Pre-B Cell Repopulation in Alpha 1,6-Fucosyltransferase Deficient Mice. Publishing Authors By Initials

W Li,K Ishihara,T Yokota,T Nakagawa,N Koyama,J Jin,Y Mizuno-Horikawa,X Wang,E Miyoshi,N Taniguchi,A Kondo,W Li,K Ishihara,T Yokota,T Nakagawa,N Koyama,J Jin,Y Mizuno-Horikawa,X Wang,E Miyoshi,N Taniguchi,A Kondo,W Li,K Ishihara,T Yokota,T Nakagawa,N Koyama,J Jin,Y Mizuno-Horikawa,X Wang,E Miyoshi,N Taniguchi,A Kondo,

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Reduced {alpha}4 1 Integrin/VCAM-1 Interactions Lead to Impaired Pre-B Cell Repopulation in Alpha 1,6-Fucosyltransferase Deficient Mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Glycobiology

VOLUME: 18

Page Numbers: 114-24

Journal Abbreviation: Glycobiology

ISSN: 0959-6658

DAY: 2

MONTH: 10

YEAR: 2007

Reduced {alpha}4 1 Integrin/VCAM-1 Interactions Lead to Impaired Pre-B Cell Repopulation in Alpha 1,6-Fucosyltransferase Deficient Mice. Information

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LANGUAGE: eng

NlmUniqueID: 9104124

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Grant and Affiliation Information for Reduced {alpha}4 1 Integrin/VCAM-1 Interactions Lead to Impaired Pre-B Cell Repopulation in Alpha 1,6-Fucosyltransferase Deficient Mice.

AFFILIATION: Departments of Glycotherapeutics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.

Country: England

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MEDLINETA: Glycobiology

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