Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder.

Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder. Research Abstract Details 

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Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder. Abstract Text:

D Allan Butterfield,Rukhsana Sultana,D Allan Butterfield,Rukhsana Sultana,

Alzheimer disease is a common age-related neurodegenerative disease characterized pathologically by senile plaques, neurofibrillary tangles, synaptic disruption, and progressive neuronal deficits. The senile plaques contain amyloid-beta (1-42) and amyloid-beta (1-40), that has been shown by a number of laboratories to induce oxidative stress and as well as neurodegeneration, although the exact mechanisms remained to be defined. Our laboratory showed an increased oxidative stress in AD and MCI brain as indexed by protein oxidation and lipid peroxidation. In the present review, we summarize our finding of oxidatively modified proteins using a redox proteomics approach in AD and MCI brain to investigate the mechanism that may be involved in MCI and AD pathogenesis and discuss our findings in terms of AD progression and pathogenesis.

Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder. Publishing Authors By Initials

DA Butterfield,R Sultana,DA Butterfield,R Sultana,

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Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of Alzheimer's disease : JAD

VOLUME: 12

Page Numbers: 61-72

Journal Abbreviation: J. Alzheimers Dis.

ISSN: 1387-2877

DAY: 13

MONTH: Aug

YEAR: 2007

Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder. Information

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LANGUAGE: eng

NlmUniqueID: 9814863

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Grant and Affiliation Information for Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder.

AFFILIATION: Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA. dabcns@uky.edu

Country: Netherlands

AGENCY: United States NIA

GRANT: AG-10836

ACRONYM: AG

MEDLINETA: J Alzheimers Dis

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