Red blood cell antioxidant enzymes in age-related macular degeneration.

Red blood cell antioxidant enzymes in age-related macular degeneration. Research Abstract Details 

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Red blood cell antioxidant enzymes in age-related macular degeneration. Abstract Text:

AIMS/BACKGROUND: Oxidative damage has been proposed to be involved in the pathogenesis of age-related macular degeneration (ARMD). The purpose of this study was to evaluate whether red blood cell antioxidant enzyme activity correlates with severity of aging maculopathy in affected individuals. METHODS: Blood samples were obtained from 54 patients with varying severity of aging maculopathy and 12 similarly aged individuals with normal ophthalmoscopic examination. Macular findings were graded according to a modification of the method described for the Age-Related Eye Disease Study. (AREDS). The activities of superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase, glutathione peroxidase, and glutathione reductase were measured in red blood cells. Haemoglobin content of whole blood was measured, and enzyme activity was determined per mg haemoglobin. RESULTS: Multiple regression analysis and ordinal logistic regression analysis were performed to determine whether antioxidant enzyme activity was associated with severity of ARMD. No significant association between disease severity of ARMD and antioxidant enzyme activity was identified for any of the enzymes. CONCLUSION: These results do not provide evidence for a relation between oxidative stress, as measured by antioxidant enzyme activity in red blood cells, and disease severity in ARMD.

Red blood cell antioxidant enzymes in age-related macular degeneration. Publishing Authors By Initials

For similar enzymes and coenzymes: enzymes: oxidoreductases: superoxide dismutase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: superoxide dismutase research

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Red blood cell antioxidant enzymes in age-related macular degeneration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The British journal of ophthalmology

VOLUME: 80

Page Numbers: 445-50

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: May

YEAR: 1996

Red blood cell antioxidant enzymes in age-related macular degeneration. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Red blood cell antioxidant enzymes in age-related macular degeneration. Keywords Mesh Terms:

KEYWORDS: Superoxide Dismutase

MESH TERMS: blood

Chemical & Substance for Abstract: Red blood cell antioxidant enzymes in age-related macular degeneration. Information

Substance Name: Superoxide Dismutase

Registry Number: EC 1.15.1.1

Grant and Affiliation Information for Red blood cell antioxidant enzymes in age-related macular degeneration.

AFFILIATION: Duke University Medical Center, Durham, NC 27710, USA.

Country: ENGLAND

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MEDLINETA: Br J Ophthalmol

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