Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats.

Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats. Research Abstract Details 

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Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats. Abstract Text:

Because of the relatively poor intestinal absorption of ampicillin sodium, efforts have been made to enhance ampicillin absorption by co-administration of absorption promoters. In the present study the enhancing effect of sodium decanoate on rate and extent of rectal ampicillin absorption in rats has been evaluated after rate-controlled and site-controlled delivery of aqueous solutions. Rectal absorption without enhancer was extremely low (8 +/- 7%), and the addition of 0.032 M sodium decanoate gave comparable values. However, administration in 0.16 M decanoate considerably increased ampicillin bioavailability, to 79 +/- 30%, whereas the absorption rate was not significantly affected.

Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats. Publishing Authors By Initials

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains research

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Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmaceutisch weekblad. Scientific edition

VOLUME: 10

Page Numbers: 76-9

Journal Abbreviation:

ISSN: 0167-6555

DAY: 22

MONTH: Apr

YEAR: 1988

Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats. Information

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LANGUAGE: eng

NlmUniqueID: 7907992

Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred Strains

MESH TERMS: drug effects

Chemical & Substance for Abstract: Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats. Information

Substance Name: Ampicillin

Registry Number: 69-53-4

Grant and Affiliation Information for Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats.

AFFILIATION: Division of Pharmacology, Sylvius Laboratories, State University of Leiden, The Netherlands.

Country: NETHERLANDS

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MEDLINETA: Pharm Weekbl Sci

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