Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen.

Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen. Research Abstract Details 

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Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen. Abstract Text:

Dengping Yin,Jing Tao,David D Lee,Jikun Shen,Manami Hara,James Lopez,Andrey Kuznetsov,Louis H Philipson,Anita S Chong,

Limitations in islet beta-cell transplantation as a therapeutic option for type 1 diabetes have prompted renewed interest in islet regeneration as a source of new islets. In this study we tested whether severely diabetic adult C57BL/6 mice can regenerate beta-cells. Diabetes was induced in C57BL/6 mice with high-dose streptozotocin (160-170 mg/kg). In the absence of islet transplantation, all diabetic mice remained diabetic (blood glucose >400 mg/dl), and no spontaneous reversal of diabetes was observed. When syngeneic islets (200/mouse) were transplanted into these diabetic mice under a single kidney capsule, stable restoration of euglycemia for >/=120 days was achieved. Removal of the kidney bearing the transplanted islets at 120 days posttransplantation revealed significant restoration of endogenous beta-cell function. This restoration of islet function was associated with increased beta-cell mass, as well as beta-cell hypertrophy and proliferation. The restoration of islet cell function was facilitated by the presence of a spleen; however, the facilitation was not due to the direct differentiation of spleen-derived cells into beta-cells. This study supports the possibility of restoring beta-cell function in diabetic individuals and points to a role for the spleen in facilitating this process.

Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen. Publishing Authors By Initials

D Yin,J Tao,DD Lee,J Shen,M Hara,J Lopez,A Kuznetsov,LH Philipson,AS Chong,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Diabetes

VOLUME: 55

Page Numbers: 3256-63

Journal Abbreviation: Diabetes

ISSN: 0012-1797

DAY: 3

MONTH: Dec

YEAR: 2006

Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372763

Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen. Information

Substance Name: Blood Glucose

Registry Number: 0

Grant and Affiliation Information for Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen.

AFFILIATION: Section of Transplantation, Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK073529

ACRONYM: DK

MEDLINETA: Diabetes

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