Recovery of cognitive function after surgery for aneurysmal subarachnoid hemorrhage.

Recovery of cognitive function after surgery for aneurysmal subarachnoid hemorrhage. Research Abstract Details 

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Recovery of cognitive function after surgery for aneurysmal subarachnoid hemorrhage. Abstract Text:

BACKGROUND AND PURPOSE: Abnormalities in neurocognitive function are common after surgery for aneurysmal subarachnoid hemorrhage, even among patients with good functional outcomes. The time course of neurocognitive recovery, along with the long-term effects of mild intraoperative hypothermia (33 degrees C) and aneurysm location, is unknown. We determined these in a subset of subarachnoid hemorrhage patients enrolled in the Intraoperative Hypothermia for Aneurysm Surgery Trial (IHAST). METHODS: We performed a longitudinal, multicenter, prospective, blinded study of adult IHAST patients with a Glasgow Outcome Score=1 or 2 (independent function), 3 months postsurgery and a matched control group (n=45). Subjects were tested with a 5-test cognitive function battery and standard neurological evaluations at 3, 9 and 15 months postsurgery. The primary outcome measure was a composite score on cognitive test performance. RESULTS: There were 303 IHAST patients available for inclusion: 218 eligible, 185 enrolled (89 hypothermic, 96 normothermic). Significant cognitive improvement was noted from 3 to 9 (P<0.001) and 3 to 15 (P<0.001) months in both hypothermic and normothermic groups, even after adjusting for practice effects observed in the control group. No significant change was identified between 9 and 15 months. Neither mild hypothermia nor aneurysm location (anterior communicating artery versus others) had a significant effect on recovery over time or frequency of cognitive impairment. Compared with control group, the frequency of cognitive impairment (Z score <-1.96) in all patients at 3, 9 and 15 months was 36%, 26% and 23%, respectively. CONCLUSIONS: In this population, cognitive improvement continued beyond 3 months, with a plateau between 9 and 15 months. This was not affected by the use of intraoperative hypothermia or anatomical location of aneurysm.

Recovery of cognitive function after surgery for aneurysmal subarachnoid hemorrhage. Publishing Authors By Initials

For similar nervous system diseases: central nervous system diseases: brain diseases: cerebrovascular disorders: intracranial hemorrhages: subarachnoid hemorrhage research abstracts see: nervous system diseases: central nervous system diseases: brain diseases: cerebrovascular disorders: intracranial hemorrhages: subarachnoid hemorrhage research

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Recovery of cognitive function after surgery for aneurysmal subarachnoid hemorrhage. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Stroke; a journal of cerebral circulation

VOLUME: 38

Page Numbers: 1864-72

Journal Abbreviation: Stroke

ISSN: 1524-4628

DAY: 12

MONTH: 04

YEAR: 2007

Recovery of cognitive function after surgery for aneurysmal subarachnoid hemorrhage. Information

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LANGUAGE: eng

NlmUniqueID: 235266

Recovery of cognitive function after surgery for aneurysmal subarachnoid hemorrhage. Keywords Mesh Terms:

KEYWORDS: Subarachnoid Hemorrhage

MESH TERMS: surgery

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Grant and Affiliation Information for Recovery of cognitive function after surgery for aneurysmal subarachnoid hemorrhage.

AFFILIATION: Department of Anesthesiology, University of Michigan Medical Center, University Hospital, Ann Arbor, MI 48109-0048, USA. satsam@umich.edu

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS 43402

ACRONYM: NS

MEDLINETA: Stroke

REFSOURCE: Stroke. 2007 Jun;38(6):1724-5

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