Reconstruction of Spatially Resolved Pharmacokinetic Rate Images of Fluorescence Agents in FDOT.

Reconstruction of Spatially Resolved Pharmacokinetic Rate Images of Fluorescence Agents in FDOT. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Reconstruction of Spatially Resolved Pharmacokinetic Rate Images of Fluorescence Agents in FDOT. Abstract Text:

B Alacam,B Yazici,A Serdaroglu,X Intes,B Chance,S Nioka,Burak Alacam,Birsen Yazici,Ahmed Serdaroglu,Xavier Intes,Britton Chance,Shoko Nioka,

In this work, we propose a method to reconstruct spatially resolved pharmacokinetic rate images of fluorescence agents directly from the boundary photon flux measurements. We use a compartmental modeling scheme to model the pharmacokinetics of fluorescence agents. We coupled this model with the fluorescence diffuse optical tomography (FDOT) forward model to form a state space model which is then iteratively solved by extended Kalman filtering (EKF) algorithm. As an example, we used a two-compartment model for indocyanine green (ICG) pharmacokinetics. To validate the proposed method, we tested our approach using a simulation study. Reconstructed pharmacokinetic rate images with correct localization of heterogeneities and high reconstruction accuracy show that the proposed algorithm can be used for tumor detection, tumor diagnosis, drug delivery and feasibility studies.

Reconstruction of Spatially Resolved Pharmacokinetic Rate Images of Fluorescence Agents in FDOT. Publishing Authors By Initials

B Alacam,B Yazici,A Serdaroglu,X Intes,B Chance,S Nioka,B Alacam,B Yazici,A Serdaroglu,X Intes,B Chance,S Nioka,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Reconstruction of Spatially Resolved Pharmacokinetic Rate Images of Fluorescence Agents in FDOT. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 1

Page Numbers: 5627-30

Journal Abbreviation:

ISSN: 1557-170X

DAY: 23

MONTH: 10

YEAR: 2006

Reconstruction of Spatially Resolved Pharmacokinetic Rate Images of Fluorescence Agents in FDOT. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101243413

Reconstruction of Spatially Resolved Pharmacokinetic Rate Images of Fluorescence Agents in FDOT. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Reconstruction of Spatially Resolved Pharmacokinetic Rate Images of Fluorescence Agents in FDOT. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Reconstruction of Spatially Resolved Pharmacokinetic Rate Images of Fluorescence Agents in FDOT.

AFFILIATION: Dept. of Electr. Comput. & Syst. Eng., Rensselaer Polytech. Inst., Troy, NY.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Conf Proc IEEE Eng Med Biol So

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Reconstruction of Spatially Resolved Pharmacokinetic Rate Images of Fluorescence Agents in FDOT Related Publications

• Characterization of Breast Tumors with NIR Methods using Optical Indices.
• Reconstruction of Spatially Resolved Pharmacokinetic Rate Images of Fluorescence Agents in FDOT.