Recognizing hidden phenotypes in sarcomas through the electron microscope.

Recognizing hidden phenotypes in sarcomas through the electron microscope. Research Abstract Details 

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Recognizing hidden phenotypes in sarcomas through the electron microscope. Abstract Text:

Differentiation along a distinct cell lineage can be identified either morphologically or with the adjunct of different ancillary techniques. While immunohistochemistry has progressively supplanted electron microscopy as the method of choice to characterize the phenotype of neoplastic cells in soft tissue tumors and in solving most differential diagnoses, a number of lesions still lack reliable specific markers or show overlapping antigen expression, which can be categorized by ultrastructural analysis through the recognition of submicroscopic features indicative of a specific line of differentiation. This review discusses the role of electron microscopy in the identification of the phenotype of neoplastic cells in soft tissue sarcomas, with particular reference to the diagnostic aspects. Sarcomas in which the cellular phenotype that can be better recognized by electron microscopy include those belonging to the fibroblastic/myofibroblastic group, particularly those displaying a poorly differentiated/pleomorphic morphology. Occasionally, in tumors with smooth muscle, skeletal muscle, adipocytic, vascular endothelial, and Schwann cell differentiation electron microscopy may help in the differential diagnosis.

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Recognizing hidden phenotypes in sarcomas through the electron microscope. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Ultrastructural pathology

VOLUME: 32

Page Numbers: 51-61

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ISSN: 1521-0758

DAY: 30

MONTH: 04

YEAR: 2008

Recognizing hidden phenotypes in sarcomas through the electron microscope. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Recognizing hidden phenotypes in sarcomas through the electron microscope.

AFFILIATION: Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy.

Country: United States

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MEDLINETA: Ultrastruct Pathol

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