Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B.

Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. Abstract Text:

Paul T Wilder,Jing Lin,Catherine L Bair,Thomas H Charpentier,Dong Yang,Melissa Liriano,Kristen M Varney,Andrew Lee,Amos B Oppenheim,Sankar Adhya,France Carrier,David J Weber,

S100B is an EF-hand containing calcium-binding protein of the S100 protein family that exerts its biological effect by binding and affecting various target proteins. A consensus sequence for S100B target proteins was published as (K/R)(L/I)xWxxIL and matches a region in the actin capping protein CapZ (V.V. Ivanenkov, G.A. Jamieson, Jr., E. Gruenstein, R.V. Dimlich, Characterization of S-100b binding epitopes. Identification of a novel target, the actin capping protein, CapZ, J. Biol. Chem. 270 (1995) 14651-14658). Several additional S100B targets are known including p53, a nuclear Dbf2 related (NDR) kinase, the RAGE receptor, neuromodulin, protein kinase C, and others. Examining the binding sites of such targets and new protein sequence searches provided additional potential target proteins for S100B including Hdm2 and Hdm4, which were both found to bind S100B in a calcium-dependent manner. The interaction between S100B and the Hdm2 and/or the Hdm4 proteins may be important physiologically in light of evidence that like Hdm2, S100B also contributes to lowering protein levels of the tumor suppressor protein, p53. For the S100B-p53 interaction, it was found that phosphorylation of specific serine and/or threonine residues reduces the affinity of the S100B-p53 interaction by as much as an order of magnitude, and is important for protecting p53 from S100B-dependent down-regulation, a scenario that is similar to what is found for the Hdm2-p53 complex.

Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. Publishing Authors By Initials

PT Wilder,J Lin,CL Bair,TH Charpentier,D Yang,M Liriano,KM Varney,A Lee,AB Oppenheim,S Adhya,F Carrier,DJ Weber,

For similar proteins: dna-binding proteins: tumor suppressor protein p53 research abstracts see: proteins: dna-binding proteins: tumor suppressor protein p53 research

PUBMED ID PMID:

MEDLINE DATE:

Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biochimica et biophysica acta

VOLUME: 1763

Page Numbers: 1284-97

Journal Abbreviation: Biochim. Biophys. Acta

ISSN: 0006-3002

DAY: 25

MONTH: 08

YEAR: 2006

Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217513

Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p53

MESH TERMS: metabolism

Chemical & Substance for Abstract: Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. Information

Substance Name: Proto-Oncogene Proteins c-mdm2

Registry Number: EC 6.3.2.19

Grant and Affiliation Information for Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B.

AFFILIATION: Department of Biochemistry and Molecular Biology, The University of Maryland School of Medicine, 108 N. Greene Street, Baltimore, MD 21201, USA.

Country: Netherlands

AGENCY: United States NCRR

GRANT: S10 RR 16812

ACRONYM: RR

MEDLINETA: Biochim Biophys Acta

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B Related Publications

• ATP synthase--the structure of the stator stalk.
• Alum with interleukin-12 augments immunity to a melanoma peptide vaccine: correlation with time to relapse in patients with resected high-risk disease.
• Assessment of contamination by polychlorinated biphenyls and aliphatic and aromatic hydrocarbons in sediments of the Santos and São Vicente Estuary System, São Paulo, Brazil.
• Bowel symptoms in women planning surgery for pelvic organ prolapse.
• Chemokines: inflammatory mediators of atherosclerosis.
• Clinical trials in cervical intraepithelial neoplasia: balancing the need for efficacy data with patient safety.
• Controlling the electrochemically active area of carbon fiber microelectrodes by the electrodeposition and selective removal of an insulating photoresist.
• Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury.
• Differential localization of the Dictyostelium kinase DPAKa during cytokinesis and cell migration.
• Effect of rhBMP-2 on guided bone regeneration in humans.
• Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea.
• Electrochemical investigation of Pb2+ binding and transport through a polymerized crystalline colloidal array hydrogel containing benzo-18-crown-6.
• Endoanal ultrasound findings and fecal incontinence symptoms in women with and without recognized anal sphincter tears.
• FDA regulation of allogeneic islets as a biological product.
• High-throughput method for lipophilicity measurement.
• Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements.
• Inflammatory mediators in atherosclerotic vascular disease.
• Inhibition of inflammatory endothelial responses by a pathway involving caspase activation and p65 cleavage.
• Perfusion MRI in CNS disease: current concepts.
• Physical activity in women planning sacrocolpopexy.
• RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium.
• Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor.
• Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B.
• Renal effects of opioid exposure: considerations for therapeutic use.
• Rydberg fingerprint spectroscopy of hot molecules: structural dispersion in flexible hydrocarbons.
• Selective cancer cell killing by alpha-tocopheryl succinate.
• Simultaneous maximization of cell permeabilization and viability in single-cell electroporation using an electrolyte-filled capillary.
• TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation.
• The conserved TFLK motif of mammary-associated serum amyloid A3 is responsible for up-regulation of intestinal MUC3 mucin expression in vitro.
• alpha-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization.