Recirculation of inhaled xenon does not alter lung CT density.

Recirculation of inhaled xenon does not alter lung CT density. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Recirculation of inhaled xenon does not alter lung CT density. Abstract Text:

Jeffrey B Hoag,Matthew Fuld,Robert H Brown,Brett A Simon,

RATIONALE AND OBJECTIVES: Xenon-enhanced computed tomography (Xe-CT) measures regional ventilation from changes in lung parenchymal CT density during the multibreath washin/washout of inhaled Xe gas. Because Xe is moderately soluble, vascular uptake and redistribution has been proposed as a confounding phenomenon. We propose that the redistribution of Xe via the circulation is negligible, and correction is unwarranted. MATERIALS AND METHODS: Unilateral ventilation with 60% Xe was performed in intubated canines. Whole-lung CT images were obtained at baseline and after 1 and 5 minutes of unilateral Xe ventilation. Comparisons between blocked (B) and Xe ventilated (V) whole lung densities were made. Density of paraspinous muscle and blood (aorta, inferior vena cava) were also compared. RESULTS: The density of lung tissue in the V lungs increased significantly compared to B lungs after 1 minute (B -688.5 +/- 54.3 Hounsfield units [HU] vs. V -535.4 +/- 55.6 HU, P < .05) and 5 minutes (B -689.1 +/- 52.2 HU vs. V -492.9 +/- 89.1 HU, P < .05) of Xe ventilation. The density in the blocked lungs did not significantly change after either 1 or 5 minutes of ventilation with Xe. Although density tended to increase with time in the blood and muscle, the change only reached significance in muscle at 5 minutes. CONCLUSIONS: Five minutes of ventilation with a high concentration of Xe does not cause measurable density changes in the contralateral, unventilated lung. Xe accumulation in muscle tissue limits redistribution. Correction of Xe-CT time series density data may be unnecessary.

Recirculation of inhaled xenon does not alter lung CT density. Publishing Authors By Initials

JB Hoag,M Fuld,RH Brown,BA Simon,

For similar inorganic chemicals: elements: noble gases: xenon research abstracts see: inorganic chemicals: elements: noble gases: xenon research

PUBMED ID PMID:

MEDLINE DATE:

Recirculation of inhaled xenon does not alter lung CT density. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Academic radiology

VOLUME: 14

Page Numbers: 81-4

Journal Abbreviation:

ISSN: 1076-6332

DAY: 3

MONTH: Jan

YEAR: 2007

Recirculation of inhaled xenon does not alter lung CT density. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9440159

Recirculation of inhaled xenon does not alter lung CT density. Keywords Mesh Terms:

KEYWORDS: Xenon

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Recirculation of inhaled xenon does not alter lung CT density. Information

Substance Name: Xenon

Registry Number: 7440-63-3

Grant and Affiliation Information for Recirculation of inhaled xenon does not alter lung CT density.

AFFILIATION: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Tower 711, The Johns Hopkins University, 600 N. Wolfe Street, Baltimore, MD 21287-8711, USA. bsimon@jhmi.edu

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL064368-06A1

ACRONYM: HL

MEDLINETA: Acad Radiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Recirculation of inhaled xenon does not alter lung CT density Related Publications

• Acidotoxicity trumps excitotoxicity in ischemic brain.
• Acute postnatal ablation of Hif-2alpha results in anemia.
• Azetidinones as vasopressin V1a antagonists.
• Binding of warfarin influences the acid-base equilibrium of H242 in sudlow site I of human serum albumin.
• CNS lymphoma in an AIDS patient involving the posterior fornix case report.
• Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons.
• Chronic ethanol consumption increases dopamine uptake in the nucleus accumbens of high alcohol drinking rats.
• Concurrent encoding of frequency and amplitude modulation in human auditory cortex: MEG evidence.
• Differential regulation of Tbx5 protein expression and sub-cellular localization during heart development.
• Dynamics of clathrin and adaptor proteins during endocytosis.
• Educational Corner: Inhibition of eosinophil apoptosis in chronic allergic disease.
• Estradiol in micellar nanoparticles: the efficacy and safety of a novel transdermal drug-delivery technology in the management of moderate to severe vasomotor symptoms.
• Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer.
• Gustatory Effects of Capsaicin that are Independent of TRPV1 Receptors.
• Hepatitis viruses in non-human primates.
• Human endometrial mucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst.
• Human standing and walking: comparison of the effects of stimulation of the vestibular system.
• Imaging single events at the cell membrane.
• Improving the filter between primary and secondary care for mental disorders.
• Mechanistic studies on the photochemical deprotection of 3',5'-dimethoxybenzoin esters.
• Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro.
• Novel therapeutic strategies via the apoptosis pathways to resolve chronic eosinophilic inflammation.
• On call: I am a 71-year-old man with diabetes and high blood pressure. Ever since I can remember, I've been bothered by painful canker sores two or three times a year. My doctor says they aren't caused by my medication and I think he's right, since the ca
• Optical monitoring of single cells using quantum dots.
• Plasminogen-mediated activation and release of hepatocyte growth factor from extracellular matrix.
• Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis.
• Recirculation of inhaled xenon does not alter lung CT density.
• Strong calcium phosphate cement-chitosan-mesh construct containing cell-encapsulating hydrogel beads for bone tissue engineering.
• The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction.
• Vascular mimetics based on microfluidics for imaging the leukocyte--endothelial inflammatory response.