Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2.

Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Abstract Text:

Hyun Lee,Peter L Whitfeld,Charles R Mackay,

Complement component C5a is one of the most potent inflammatory chemoattractants and has been implicated in the pathogenesis of numerous inflammatory diseases. C5a binds two receptors, C5aR and C5L2. Most of the C5a functional effects occur through C5aR, and the pharmaceutical industry has focused on this receptor for the development of new anti-inflammatory therapies. We used a novel approach to generate and test therapeutics that target C5aR. We created human C5aR knock-in mice, and used neutrophils from these to immunize wild-type mice. This yielded high-affinity blocking mAbs to human C5aR. We tested these anti-human C5aR mAbs in mouse models of inflammation, using the human C5aR knock-in mice. These antibodies completely prevented disease onset and were also able to reverse established disease in the K/B x N arthritis model. The physiological role of the other C5a receptor, C5L2 is still unclear, and our studies with blocking mAbs to human C5L2 have failed to demonstrate a clear functional role in signaling to C5a. The development of effective mAbs to human C5aR is an alternative approach to drug development, for this highly attractive target.Immunology and Cell Biology (2008) 86, 153-160; doi:10.1038/sj.icb.7100166; published online 29 January 2008.

Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Publishing Authors By Initials

H Lee,PL Whitfeld,CR Mackay,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Immunology and cell biology

VOLUME: 86

Page Numbers: 153-60

Journal Abbreviation: Immunol. Cell Biol.

ISSN: 0818-9641

DAY: 29

MONTH: 01

YEAR: 2008

Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8706300

Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2.

AFFILIATION: 1Immunology and Inflammation Department, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

Country: Australia

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Immunol Cell Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Receptors for complement C5a The importance of C5aR and the enigmatic role of C5L2 Related Publications

• A comparison of the respiratory activity and histological changes in isolated pancreatic tissue.
• A randomised, split-face comparison of facial hair removal with the alexandrite laser and intense pulsed light system.
• A study of asthma in schoolchildren.
• A survey of current surgical treatment of acute gallstone disease in the west of Scotland.
• AAPL Practice Guideline for the Forensic Psychiatric Evaluation of Competence to Stand Trial: An English Legal Perspective.
• Acute rheumatism.
• Autoimmune diseases of the liver, autoimmune hepatitis and primary biliary cirrhosis: Unfinished business.
• Autoimmunity since the 1957 clonal selection theory: a little acorn to a large oak.
• Cancrum oris among African natives.
• Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping.
• Cerebral angiography in neurologic diagnosis.
• Dentistry on stamps. George Leslie MacKay.
• Effect of 1-epinephrine and 1-arterenol on egg white edema in the rat.
• Effect of 11-desoxycorticosterone acetate upon carbohydrate utilization by the depancreatized rat.
• Evaluation of Gafchromic EBT Film for Prostate IMRT Verification.
• High-resolution mapping of quantitative trait loci affecting increased life span in Drosophila melanogaster.
• Insulin stimulation of glycogen formation in rat abdominal muscle.
• Leucotomy in the treatment of psychopathic feeble-minded patients in a state mental deficiency institution.
• Long T(2) water in multiple sclerosis: What else can we learn from multi-echo T(2) relaxation?
• MR evidence of long T2 water in pathological white matter.
• Multiplication and division by electronic-analogue methods.
• NPY and receptors in immune and inflammatory diseases.
• Quantitative genomics of aggressive behavior in Drosophila melanogaster.
• Quantitative trait loci for locomotor behavior in Drosophila melanogaster.
• Regions of nonexistence of invariant tori for spin-orbit models.
• Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2.
• Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology.
• The effect of surgical devascularization of the stomach on the production of Mann-Williamson ulcers.
• The influence of insulin and adrenal cortical compounds on the metabolism of radioactive C14-glucose in the isolated rat diaphragm.
• Ts18p post injury multiple organ failure: the Australian context.