Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells.

Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells. Research Abstract Details 

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Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells. Abstract Text:

J Krishnan,P A Iglesias,

Polarization--the clear and persistent localization of different signaling molecules to opposite ends of the cell-is critical for effective chemotaxis in eukaryotic systems. In many systems, polarization can also occur without an externally imposed chemical gradient. We build a modeling framework to study the relationship between the intrinsic capacity for polarization, and that induced by an external gradient. Working within this framework, we analyze different scenarios for the interaction of these pathways. The models are qualitatively simplified, motivated by known properties of the signaling pathways. We also examine the possible role of nonlinear transitions occurring in the polarization pathways. The modeling framework generates testable predictions regarding the relationship between intrinsic polarization and that induced during chemotaxis, and is the first step toward a systematic analysis of the interaction between these pathways.

Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells. Publishing Authors By Initials

J Krishnan,PA Iglesias,

For similar proteins: membrane proteins: receptors, cell surface research abstracts see: proteins: membrane proteins: receptors, cell surface research

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Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biophysical journal

VOLUME: 92

Page Numbers: 816-30

Journal Abbreviation: Biophys. J.

ISSN: 0006-3495

DAY: 3

MONTH: 11

YEAR: 2006

Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells. Information

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LANGUAGE: eng

NlmUniqueID: 370626

Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells. Keywords Mesh Terms:

KEYWORDS: Receptors, Cell Surface

MESH TERMS: metabolism

Chemical & Substance for Abstract: Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells. Information

Substance Name: Receptors, Cell Surface

Registry Number: 0

Grant and Affiliation Information for Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells.

AFFILIATION: Chemical Engineering and Chemical Technology, Imperial College, London, United Kingdom.

Country: United States

AGENCY: United States PHS

GRANT: 71920

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MEDLINETA: Biophys J

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