Recent outcome of Graves' disease patients with papillary thyroid cancer.

Recent outcome of Graves' disease patients with papillary thyroid cancer. Research Abstract Details 

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Recent outcome of Graves' disease patients with papillary thyroid cancer. Abstract Text:

Yukiko Yano,Hiroshi Shibuya,Wataru Kitagawa,Mitsuji Nagahama,Kiminori Sugino,Kunihiko Ito,Koichi Ito,

OBJECTIVE: The objective was to evaluate the clinical behavior and outcome of 202 papillary thyroid cancers in Graves' disease patients during the period 1994-2004. DESIGN: This was a retrospective, non-randomized case-control study. METHODS: Since 1994, we have included an ultrasonogram of the neck in the initial examination of thyroid disease patients who consult our outpatient clinic. We evaluated the tumor status and long-term outcome of Graves' disease patients with thyroid cancer and of age- and tumor size-matched euthyroid papillary thyroid cancer patients as controls. Serum TSH receptor antibody (TRAb) was measured in the Graves' disease group. RESULTS: A total of 154 papillary thyroid cancers were diagnosed in the Graves' disease patients and were treated surgically. At surgery, no significant differences in multifocality, lymph node metastasis, or distant metastasis were found between the Graves' disease group and the euthyroid group. On the whole, the clinical course of the cancers in both the Graves' disease group and euthyroid group was relatively good. No significant correlations were found between the TRAb levels in the Graves' disease group and multifocality or the presence of lymph node metastasis. Papillary thyroid cancer was discovered as an incidental finding in 2% of the 2356 surgically treated Graves' disease patients, but none of them developed metastasis during the follow-up period. CONCLUSION: The results in this series of patients do not support the claim that thyroid cancer is more aggressive in Graves' disease patients than in euthyroid patients.

Recent outcome of Graves' disease patients with papillary thyroid cancer. Publishing Authors By Initials

Y Yano,H Shibuya,W Kitagawa,M Nagahama,K Sugino,K Ito,K Ito,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Recent outcome of Graves' disease patients with papillary thyroid cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of endocrinology / European Feder

VOLUME: 157

Page Numbers: 325-9

Journal Abbreviation: Eur. J. Endocrinol.

ISSN: 0804-4643

DAY: 19

MONTH: Sep

YEAR: 2007

Recent outcome of Graves' disease patients with papillary thyroid cancer. Information

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LANGUAGE: eng

NlmUniqueID: 9423848

Recent outcome of Graves' disease patients with papillary thyroid cancer. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: surgery

Chemical & Substance for Abstract: Recent outcome of Graves' disease patients with papillary thyroid cancer. Information

Substance Name: thyrotropin-binding inhibitory immunoglo

Registry Number: 0

Grant and Affiliation Information for Recent outcome of Graves' disease patients with papillary thyroid cancer.

AFFILIATION: Ito Hospital, 4-3-6 Jinngu-Mae, Shibuya, Tokyo, Japan. geka@ito-hospital.jp

Country: England

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MEDLINETA: Eur J Endocrinol

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