Recent advances on pathogenesis and therapies in systemic sclerosis.

Recent advances on pathogenesis and therapies in systemic sclerosis. Research Abstract Details 

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Recent advances on pathogenesis and therapies in systemic sclerosis. Abstract Text:

Norihito Yazawa,Manabu Fujimoto,Kunihiko Tamaki,Norihito Yazawa,Manabu Fujimoto,Kunihiko Tamaki,

Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by extensive fibrotic changes in various organs, including skin and lung. Although the etiology of SSc remains unknown, three major abnormalities, abnormal humoral immunity, microvasculature, and fibroblast dysfunctions are considered to play important roles. Significant progress has been made in understanding the pathogenesis on SSc, and has been also providing clues to the treatment for this disease. This review summarizes recent advances on the pathogenesis and new therapeutic strategy for SSc.

Recent advances on pathogenesis and therapies in systemic sclerosis. Publishing Authors By Initials

N Yazawa,M Fujimoto,K Tamaki,N Yazawa,M Fujimoto,K Tamaki,

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Recent advances on pathogenesis and therapies in systemic sclerosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical reviews in allergy & immunology

VOLUME: 33

Page Numbers: 107-12

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ISSN: 1080-0549

DAY: 20

MONTH: Oct

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo, 113-8655, Japan, yazawa-DER@h.u-tokyo.ac.jp.

Country: United States

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MEDLINETA: Clin Rev Allergy Immunol

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