Recent advances in understanding endogenous fibrinolysis: implications for molecular-based treatment of vascular disorders.

Recent advances in understanding endogenous fibrinolysis: implications for molecular-based treatment of vascular disorders. Research Abstract Details 

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Recent advances in understanding endogenous fibrinolysis: implications for molecular-based treatment of vascular disorders. Abstract Text:

Peter F Bodary,Kevin J Wickenheiser,Daniel T Eitzman,

The fate of a forming thrombus is determined through the delicate balance between the coagulation cascade, favouring clot formation, and the fibrinolytic system, favouring clot lysis. These processes occur simultaneously, and enhancement of fibrinolysis has been shown to reduce occlusive thrombus formation in animal models. This review examines the roles of the major fibrinolytic factors involved in clot lysis. The regulation of plasmin activity by plasminogen activators, alpha-2-antiplasmin, plasminogen activator inhibitor 1, and thrombin-activatable fibrinolysis inhibitor, and their effects on thrombus formation in vivo are discussed. Since alterations in fibrinolytic capacity appear to affect thrombus formation in animal models, there is considerable interest in the pharmacological manipulation of fibrinolysis.

Recent advances in understanding endogenous fibrinolysis: implications for molecular-based treatment of vascular disorders. Publishing Authors By Initials

PF Bodary,KJ Wickenheiser,DT Eitzman,

For similar cardiovascular diseases: vascular diseases research abstracts see: cardiovascular diseases: vascular diseases research

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Recent advances in understanding endogenous fibrinolysis: implications for molecular-based treatment of vascular disorders. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert reviews in molecular medicine

VOLUME: 4

Page Numbers: 1-10

Journal Abbreviation:

ISSN: 1462-3994

DAY: 26

MONTH: 03

YEAR: 2002

Recent advances in understanding endogenous fibrinolysis: implications for molecular-based treatment of vascular disorders. Information

Number of References: 73

LANGUAGE: eng

NlmUniqueID: 100939725

Recent advances in understanding endogenous fibrinolysis: implications for molecular-based treatment of vascular disorders. Keywords Mesh Terms:

KEYWORDS: Vascular Diseases

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Recent advances in understanding endogenous fibrinolysis: implications for molecular-based treatment of vascular disorders. Information

Substance Name: Fibrinolytic Agents

Registry Number: 0

Grant and Affiliation Information for Recent advances in understanding endogenous fibrinolysis: implications for molecular-based treatment of vascular disorders.

AFFILIATION: Division of Cardiology, University of Michigan Medical Center, 7315 MSRB III, 1150 W. Medical Center Drive, Ann Arbor, MI 49109-0644, USA. pfbodary@umich.edu

Country: England

AGENCY: United States NHLBI

GRANT: P01HL-5734

ACRONYM: HL

MEDLINETA: Expert Rev Mol Med

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