Recent advances in the measurement of adiponectin isoform distribution.

Recent advances in the measurement of adiponectin isoform distribution. Research Abstract Details 

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Recent advances in the measurement of adiponectin isoform distribution. Abstract Text:

Faidon Magkos,Labros S Sidossis,

PURPOSE OF REVIEW: Adiponectin has potent antidiabetic and antiatherosclerotic actions. Recent studies in animals and humans suggest that the high-molecular weight adiponectin complex, consisting of many adiponectin monomers, is the biologically active form of the peptide. This article will present recent methodological approaches for analyzing adiponectin isoform distribution. RECENT FINDINGS: A handful of methods have been used for the isolation and measurement of high-molecular weight adiponectin, based on velocity gradient centrifugation, gel filtration chromatography and polyacrylamide gel electrophoresis. Recently, two novel sandwich enzyme-linked immuno-sorbent assays have been developed. The first makes use of antibodies raised against human high-molecular weight adiponectin and thus allows for the specific determination of high-molecular weight adiponectin in plasma. The second and more versatile enzyme-linked immuno-sorbent assay system enables the measurement of all adiponectin isoforms (i.e. low, middle and high-molecular weight) by means of selective digestion by proteases. SUMMARY: The development and commercial availability of novel enzyme-linked immuno-sorbent assay kits enables the easy and rapid measurement of high-molecular weight adiponectin in both research and clinical practice and will undoubtedly advance further our understanding of the role of adiponectin in health and disease.

Recent advances in the measurement of adiponectin isoform distribution. Publishing Authors By Initials

F Magkos,LS Sidossis,

For similar proteins: protein isoforms research abstracts see: proteins: protein isoforms research

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Recent advances in the measurement of adiponectin isoform distribution. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in clinical nutrition and metaboli

VOLUME: 10

Page Numbers: 571-5

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ISSN: 1363-1950

DAY: 3

MONTH: Sep

YEAR: 2007

Recent advances in the measurement of adiponectin isoform distribution. Information

Number of References: 41

LANGUAGE: eng

NlmUniqueID: 9804399

Recent advances in the measurement of adiponectin isoform distribution. Keywords Mesh Terms:

KEYWORDS: Protein Isoforms

MESH TERMS: immunology

Chemical & Substance for Abstract: Recent advances in the measurement of adiponectin isoform distribution. Information

Substance Name: adiponectin, human

Registry Number: 0

Grant and Affiliation Information for Recent advances in the measurement of adiponectin isoform distribution.

AFFILIATION: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.

Country: England

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MEDLINETA: Curr Opin Clin Nutr Metab Care

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