Recent advances in enteric neurobiology: mechanosensitive interneurons.

Recent advances in enteric neurobiology: mechanosensitive interneurons. Research Abstract Details 

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Recent advances in enteric neurobiology: mechanosensitive interneurons. Abstract Text:

T K Smith,N J Spencer,G W Hennig,E J Dickson,T K Smith,N J Spencer,G W Hennig,E J Dickson,

Until recently, it was generally assumed that the only intrinsic sensory neuron, or primary afferent neuron, in the gut was the after-hyperpolarizing AH/Type II neuron. AH neurons excited by local chemical and mechanical stimulation of the mucosa appear to be necessary for activating the peristaltic reflex (oral excitation and anal inhibition of the muscle layers) and anally propagating ring like contractions (peristaltic waves) that depend upon smooth muscle tone. However, our recent findings in the guinea-pig distal colon suggest that different neurochemical classes of interneuron in the colon are also mechanosensitive in that they respond directly to changes in muscle length, rather than muscle tone or tension. These interneurons have electrophysiological properties consistent with myenteric S-neurons. Ascending and descending interneurons respond directly to circumferential stretch by generating an ongoing polarized peristaltic reflex activity (oral excitatory and anal inhibitory junction potentials) in the muscle for as long as the stimulus is maintained. Some descending (nitric oxide synthase +ve) interneurons, on the other hand, appear to respond directly to longitudinal stretch and are involved in accommodation and slow transit of faecal pellets down the colon. This review will present recent evidence that suggests some myenteric S interneurons, in addition to AH neurons, behave as intrinsic sensory neurons.

Recent advances in enteric neurobiology: mechanosensitive interneurons. Publishing Authors By Initials

TK Smith,NJ Spencer,GW Hennig,EJ Dickson,TK Smith,NJ Spencer,GW Hennig,EJ Dickson,

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Recent advances in enteric neurobiology: mechanosensitive interneurons. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neurogastroenterology and motility : the official

VOLUME: 19

Page Numbers: 869-78

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ISSN: 1350-1925

DAY: 8

MONTH: Nov

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9432572

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Grant and Affiliation Information for Recent advances in enteric neurobiology: mechanosensitive interneurons.

AFFILIATION: Department of Physiology & Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA. tks@physio.unr.edu

Country: England

AGENCY: United States NIDDK

GRANT: R01 DK45713

ACRONYM: DK

MEDLINETA: Neurogastroenterol Motil

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