Recapitulation of embryological programmes in renal fibrosis--the importance of epithelial cell plasticity and developmental genes.

Recapitulation of embryological programmes in renal fibrosis--the importance of epithelial cell plasticity and developmental genes. Research Abstract Details 

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Recapitulation of embryological programmes in renal fibrosis--the importance of epithelial cell plasticity and developmental genes. Abstract Text:

Chronic fibrosis represents the final common pathway in progressive renal disease. Myofibroblasts deposit the constituents of renal scar, thus crippling renal function. It has recently emerged that an important source of these pivotal effector cells is the injured renal epithelium. This review concentrates on the process of epithelial-mesenchymal transition (EMT) and its regulation. The role of the developmental gene, gremlin, which is reactivated in adult renal disease, is the subject of particular focus. This member of the cysteine knot protein superfamily is critical to the process of nephrogenesis but quiescent in normal adult kidney. There is increasing evidence that gremlin expression reactivates in diabetic nephropathy, and in the diseased fibrotic kidney per se. Known to antagonize members of the bone morphogenic protein (BMP) family, gremlin may also act downstream of TGF-beta in induction of EMT. An increased understanding of the extracellular modulation of EMT and, in particular, of the gremlin-BMP axis may result in strategies that can halt or reverse the devastating progression of chronic renal fibrosis.

Recapitulation of embryological programmes in renal fibrosis--the importance of epithelial cell plasticity and developmental genes. Publishing Authors By Initials

For similar embryonic structures: germ layers: mesoderm research abstracts see: embryonic structures: germ layers: mesoderm research

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Recapitulation of embryological programmes in renal fibrosis--the importance of epithelial cell plasticity and developmental genes. Journal Published:

PUBLICATION TYPE: Review

Journal: Nephron. Physiology

VOLUME: 103

Page Numbers: p139-48

Journal Abbreviation: Nephron Physiol

ISSN: 1660-2137

DAY: 23

MONTH: 03

YEAR: 2006

Recapitulation of embryological programmes in renal fibrosis--the importance of epithelial cell plasticity and developmental genes. Information

Number of References: 70

LANGUAGE: eng

NlmUniqueID: 101159772

Recapitulation of embryological programmes in renal fibrosis--the importance of epithelial cell plasticity and developmental genes. Keywords Mesh Terms:

KEYWORDS: Mesoderm

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Recapitulation of embryological programmes in renal fibrosis--the importance of epithelial cell plasticity and developmental genes. Information

Substance Name: Intercellular Signaling Peptides and Pro

Registry Number: 0

Grant and Affiliation Information for Recapitulation of embryological programmes in renal fibrosis--the importance of epithelial cell plasticity and developmental genes.

AFFILIATION: UCD School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.

Country: Switzerland

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MEDLINETA: Nephron Physiol

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