Recall injection-site reactions associated with etanercept therapy: report of two new cases with immunohistochemical analysis.

Recall injection-site reactions associated with etanercept therapy: report of two new cases with immunohistochemical analysis. Research Abstract Details 

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Recall injection-site reactions associated with etanercept therapy: report of two new cases with immunohistochemical analysis. Abstract Text:

M A ,V M ,M C ,R Blanco,H ,V ,J F Val-Bernal,M A ,V M ,M C ,R Blanco,H ,V ,J F Val-Bernal,

Injection site reactions (ISRs) are the most common adverse effect reported with etanercept therapy. It has been observed that some patients treated with etanercept develop ''recall ISRs'', that are reactions at sites where etanercept was previously injected after the last injection. Etanercept-associated recall ISRs have been scarcely published. We report two patients with rheumatoid arthritis who developed recall ISRs during etanercept therapy. Biopsy specimens from ISRs demonstrated a superficial perivascular lymphocytic infiltrated with a few eosinophils. Immunohistochemical study in both cases revealed that T cells bearing a CD4+ phenotype mostly composed the inflammatory infiltrate. Our observations suggest that ISRs may be mediated by classic cellular-hypersensitivity reactions directed by CD4+ T lymphocytes.

Recall injection-site reactions associated with etanercept therapy: report of two new cases with immunohistochemical analysis. Publishing Authors By Initials

MA ,VM ,MC ,R Blanco,H ,V ,JF Val-Bernal,MA ,VM ,MC ,R Blanco,H ,V ,JF Val-Bernal,

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Recall injection-site reactions associated with etanercept therapy: report of two new cases with immunohistochemical analysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental dermatology

VOLUME: 32

Page Numbers: 672-4

Journal Abbreviation: Clin. Exp. Dermatol.

ISSN: 0307-6938

DAY: 23

MONTH: Nov

YEAR: 2007

Recall injection-site reactions associated with etanercept therapy: report of two new cases with immunohistochemical analysis. Information

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LANGUAGE: eng

NlmUniqueID: 7606847

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AFFILIATION: Department of Dermatology, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain.

Country: England

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MEDLINETA: Clin Exp Dermatol

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