Reassessing the role of phosphocaveolin-1 in cell adhesion and migration.

Reassessing the role of phosphocaveolin-1 in cell adhesion and migration. Research Abstract Details 

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Reassessing the role of phosphocaveolin-1 in cell adhesion and migration. Abstract Text:

Michelle M Hill,Nadja Scherbakov,Natalia Schiefermeier,Joanne Baran,John F Hancock,Lukas A Huber,Robert G Parton,Marie-Odile Parat,Michelle M Hill,Nadja Scherbakov,Natalia Schiefermeier,Joanne Baran,John F Hancock,Lukas A Huber,Robert G Parton,Marie-Odile Parat,Michelle M Hill,Nadja Scherbakov,Natalia Schiefermeier,Joanne Baran,John F Hancock,Lukas A Huber,Robert G Parton,Marie-Odile Parat,

Although phosphorylation on tyrosine 14 was identified early in the discovery of caveolin-1, the functional significance of this modification still remains elusive. Recent evidence points to a role of caveolin-1 tyrosine 14 phosphorylation in cell adhesion and migration. These results are based on a variety of tools, including a widely used mouse monoclonal anti-phosphocaveolin-1 antibody, which labels, in cultured cells, a protein localized at or near focal adhesions. We here report results from three independent laboratories, showing that this antibody recognizes phosphocaveolin-1 amongst other proteins in immunoblot analyses and that the signal obtained with this antibody in immunostaining experiments is in part due to labeling of paxillin. Published data need to be interpreted keeping in mind that images of phosphocaveolin-1 cellular localization obtained using this antibody are not valid. We re-evaluate the current knowledge about the role of caveolin-1 in cell adhesion and migration in view of this new information.

Reassessing the role of phosphocaveolin-1 in cell adhesion and migration. Publishing Authors By Initials

MM Hill,N Scherbakov,N Schiefermeier,J Baran,JF Hancock,LA Huber,RG Parton,MO Parat,MM Hill,N Scherbakov,N Schiefermeier,J Baran,JF Hancock,LA Huber,RG Parton,MO Parat,MM Hill,N Scherbakov,N Schiefermeier,J Baran,JF Hancock,LA Huber,RG Parton,MO Parat,

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Reassessing the role of phosphocaveolin-1 in cell adhesion and migration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Traffic (Copenhagen, Denmark)

VOLUME: 8

Page Numbers: 1695-705

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ISSN: 1398-9219

DAY: 7

MONTH: 10

YEAR: 2007

Reassessing the role of phosphocaveolin-1 in cell adhesion and migration. Information

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LANGUAGE: eng

NlmUniqueID: 100939340

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AFFILIATION: Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072, Australia.

Country: Denmark

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MEDLINETA: Traffic

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