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[Reappraisal of risk factors predicting liver complications from radiotherapy for hepatocellular carcinoma]

[Reappraisal of risk factors predicting liver complications from radiotherapy for hepatocellular carcinoma] Research Abstract Details 

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  • [Reappraisal of risk factors predicting liver complications from radiotherapy for hepatocellular carcinoma] Abstract Text:

    ik jae leeIk Jae Lee,jinsil seongJinsil Seong,su jung shimSu Jung Shim,kwang hyub hanKwang Hyub Han,chae yoon chonChae Yoon Chon,

    BACKGROUND/AIMS: Determination of the optimal radiotherapeutic parameters for radiotherapy of hepatocellular carcinoma (HCC) is still under investigation. The purpose of this study is to identify the risk factors associated with radiation-related morbidity. METHODS: We evaluated one hundred fifty-eight patients, who were given radiotherapy for HCC between January 1992 and March 2000. Radiation-induced liver disease (RILD) was defined as the development of nonmalignant ascites without disease progression and an anicteric elevation of the alkaline phosphatase level by at least twofold. Gastrointestinal toxicity was assessed by using the RTOG-EORTC scale. RESULTS: Six patients (3.8%) displayed RILD. In these patients, three patients had not responded to other previous treatments. Two patients with portal vein thrombosis or huge sized mass, above 10 cm, showed liver toxicity and two other patients presented with Child-Pugh class B liver cirrhosis. Eight patients (5%) had gastro-duodenal ulcers. In one of these 8 patients, the left lobe close to the stomach was involved and two patients had been treated for gastro-duodenal ulcer. In two more patients, the radiation field, with using anterior/posterior radiation ports, covered a significant volume of the gastrointestinal tract. One of eight patients had been irradiated with a large fraction size (250 cGy). CONCLUSIONS: The efforts should be made to reduce the radiation-related complications for hepatocellular carcinoma by considering the volume and the function of remaining liver, the location of tumor, the tumor size and the severity of liver cirrhosis.

    [Reappraisal of risk factors predicting liver complications from radiotherapy for hepatocellular carcinoma] Publishing Authors By Initials

    ij leeIJ Lee,j seongJ Seong,sj shimSJ Shim,kh hanKH Han,cy chonCY Chon,

    For similar abstracts research abstracts see: abstracts research

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    [Reappraisal of risk factors predicting liver complications from radiotherapy for hepatocellular carcinoma] Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: The Korean journal of hepatology

    VOLUME: 12

    Page Numbers: 420-8

    Journal Abbreviation:

    ISSN: 1738-222X

    DAY: 25

    MONTH: Sep

    YEAR: 2006

    [Reappraisal of risk factors predicting liver complications from radiotherapy for hepatocellular carcinoma] Information

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    LANGUAGE: kor

    NlmUniqueID: 101211947

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    Grant and Affiliation Information for [Reappraisal of risk factors predicting liver complications from radiotherapy for hepatocellular carcinoma]

    AFFILIATION: Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.

    Country: Korea (South)

    Korea (South) Research PublicationKorea (South) Research Publication

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    MEDLINETA: Korean J Hepatol

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