Realgar Nanoparticles Induced Cytotoxicity in Promyelocytic Leukemia HL-60 Cells.

Realgar Nanoparticles Induced Cytotoxicity in Promyelocytic Leukemia HL-60 Cells. Research Abstract Details 

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Realgar Nanoparticles Induced Cytotoxicity in Promyelocytic Leukemia HL-60 Cells. Abstract Text:

H Ye,X Yang,L Gan,X Sun,H Xu,

Realgar, one of mineral drugs in Chinese traditional medicines has attracted an increasing attention because of its prominent anti-tumor effect. However, new challenges for improving its bioavailability has to be faced. Our previous studies have demonstrated that realgar nanoparticles may provide a less toxic agent for anti-neoplasia by suppressing angiogenesis. In the present study, we improved milling process, prepared raw realgar particles and realgar nanoparticles with the same background As2O3concentrations and compared their cytoxcity to promyelocytic leukemia HL-60 cells including inhibiting cell growth, inducing oxidative stress. It was found that treatment with realgar nanoparticles resulted in considerably low cell viability compared with raw realgar particles. On the other hand, treatement with realgar nanoparticles promoted the generations of reactive oxygen species (ROS) and inhibited the activity of catalase (CAT), which was accompanied by lipid peroxidation and protein oxidation, especially the loss of its free thiols, whereas such events was not observed in HL-60 cells exposed to raw realgar particles. These results suggest that realgar nanoparticles are superior over raw realgar particles for their cytotoxicity including inhibition of cell proliferation and enhanced effects of oxidative stress, which may provide a possibility for its application in tumor therapy.

Realgar Nanoparticles Induced Cytotoxicity in Promyelocytic Leukemia HL-60 Cells. Publishing Authors By Initials

H Ye,X Yang,L Gan,X Sun,H Xu,

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Realgar Nanoparticles Induced Cytotoxicity in Promyelocytic Leukemia HL-60 Cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 7

Page Numbers: 7714-7

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ISSN: 1557-170X

DAY: 6

MONTH: 02

YEAR: 2005

Realgar Nanoparticles Induced Cytotoxicity in Promyelocytic Leukemia HL-60 Cells. Information

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LANGUAGE: eng

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AFFILIATION: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074 P. R. China. (e-mail: hanqingye@hotmail.com).

Country: United States

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MEDLINETA: Conf Proc IEEE Eng Med Biol So

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