Real-time control of the energy landscape by force directs the folding of RNA molecules.

Real-time control of the energy landscape by force directs the folding of RNA molecules. Research Abstract Details 

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Real-time control of the energy landscape by force directs the folding of RNA molecules. Abstract Text:

Pan T X Li,Carlos Bustamante,Ignacio Tinoco,

The rugged folding-energy landscapes of RNAs often display many competing minima. How do RNAs discriminate among competing conformations in their search for the native state? By using optical tweezers, we show that the folding-energy landscape can be manipulated to control the fate of an RNA: individual RNA molecules can be induced into either native or misfolding pathways by modulating the relaxation rate of applied force and even be redirected during the folding process to switch from misfolding to native folding pathways. Controlling folding pathways at the single-molecule level provides a way to survey the manifold of folding trajectories and intermediates, a capability that previously was available only to theoretical studies.

Real-time control of the energy landscape by force directs the folding of RNA molecules. Publishing Authors By Initials

PT Li,C Bustamante,I Tinoco,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Real-time control of the energy landscape by force directs the folding of RNA molecules. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 7039-44

Journal Abbreviation:

ISSN: 0027-8424

DAY: 16

MONTH: 04

YEAR: 2007

Real-time control of the energy landscape by force directs the folding of RNA molecules. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

Real-time control of the energy landscape by force directs the folding of RNA molecules. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Real-time control of the energy landscape by force directs the folding of RNA molecules. Information

Substance Name: RNA

Registry Number: 63231-63-0

Grant and Affiliation Information for Real-time control of the energy landscape by force directs the folding of RNA molecules.

AFFILIATION: Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. panli@albany.edu

Country: United States

AGENCY: United States NIGMS

GRANT: GM 32543

ACRONYM: GM

MEDLINETA: Proc Natl Acad Sci U S A

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