Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys.

Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys. Abstract Text:

Jul Lea Shamy,Cindy A Buckmaster,David G Amaral,Michael E Calhoun,Peter R Rapp,

Hippocampal structural plasticity induced by entorhinal cortex (EC) lesions has been studied extensively in the rat, but little comparable research has been conducted in primates. In the current study we assessed the long-term effects of bilateral aspiration lesions of the EC on multiple markers of circuit organization in the hippocampal dentate gyrus of young adult monkeys (Macaca fascicularis). Alternate histological sections were processed for the visualization of somatostatin and vesicular acetylcholine transporter (VAChT) immunoreactivity and acetylcholinesterase histochemistry (AChE). The markers revealed the distinct laminar organization of dentate gyrus circuitry for stereology-based morphometric quantification. Consistent with findings in rats, the volume of the somatostatin-immunopositive outer molecular layer (OML), innervated by projections from the EC, was decreased by 42% relative to control values. The inner molecular layer (IML) displayed a corresponding volumetric expansion in response to denervation of the OML as measured by AChE staining, but not when visualized for quantification by VAChT immunoreactivity. Nonetheless, stereological estimation revealed a 36% increase in the total length of VAChT-positive cholinergic fibers in the IML after EC damage, along with no change in the OML. Together, these findings suggest that despite substantial species differences in the organization of hippocampal circuitry, the capacity for reactive plasticity following EC damage, previously documented in rats, is at least partly conserved in the primate dentate gyrus.

Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys. Publishing Authors By Initials

JL Shamy,CA Buckmaster,DG Amaral,ME Calhoun,PR Rapp,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of comparative neurology

VOLUME: 502

Page Numbers: 192-201

Journal Abbreviation: J. Comp. Neurol.

ISSN: 0021-9967

DAY: 10

MONTH: May

YEAR: 2007

Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 406041

Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys. Keywords Mesh Terms:

KEYWORDS: Vesicular Acetylcholine Transport Protei

MESH TERMS: metabolism

Chemical & Substance for Abstract: Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys. Information

Substance Name: Acetylcholinesterase

Registry Number: EC 3.1.1.7

Grant and Affiliation Information for Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys.

AFFILIATION: Fishberg Department of Neuroscience & Alfred B and Gundren J Kastor Neurobiology Aging Laboratories, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS32892

ACRONYM: NS

MEDLINETA: J Comp Neurol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys Related Publications

• (Na+,K+)-activated adenosinetriphosphatase and hypertension in DAHL salt- sensitive and -resistant rats.
• A controlled comparison between imipramine and protriptyline.
• A phylogenetic theory of wit and humor.
• Apoptosis regulation by Raf, Bcl-2, and R-Ras.
• Basic principles of roentgenology.
• Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation.
• Chlorophyll, the green wonder drug.
• Detection of clinically silent infarcts after carotid endarterectomy by use of diffusion-weighted imaging.
• Dysmenorrhea.
• Eliminating adverse drug events at Ascension Health.
• Evaluation of conceptual selling(r) as a job development planning process.
• Lack of effects of maternal salt intake on blood pressure of offspring in Dahl salt-sensitive rats.
• Lexical and post-lexical phonological representations in spoken production.
• MRI of geometric and compositional features of vulnerable carotid plaque.
• Normal values for serum amylase and maltase in dogs and the effect of maltase on the saccharogenic method of determining amylase in serum.
• Objective evaluation of EEG amplitude in chronic schizophrenic patients during a controlled trial of pimozide and trifluoperazine.
• Organic rodenticides.
• Quantitation of renal renin and renin mRNA in Dahl rats in response to provocative stimuli.
• Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys.
• Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism.
• Responses to calcium of chemically skinned vascular smooth muscle from spontaneously hypertensive rats.
• Serum levels of phenylalanine and tyrosine in Huntington's chorea.
• Simulation of the MRI measurement of diffusion in realistic neural tissue models.
• The Ras-Raf relationship: an unfinished puzzle.
• The role of Raf kinases in development and growth of tumors.
• The strengths perspective: proving "my strengths" and '"it work".
• [Herpesvirus and human cancer]
• [Not Available.]
• [Postpartum cerebral thrombophlebitis; cure.]
• [The leukocyte migration test (LMT) in carcinoma of the stomach and nonmalignant stomach diseases : evidence for the appearance of tumor-associated antigens]