Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin.

Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin. Research Abstract Details 

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Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin. Abstract Text:

Gordon C Hard,John Curtis Seely,Laura J Betz,Shim-Mo Hayashi,

Renal histopathology in the most recent 2-year carcinogenicity bioassay of quercetin, in Fischer 344 rats, was re-evaluated in an attempt to determine a mode of action underlying a small increase in renal tubule tumors reported in the males (). The re-evaluation confirmed the reported increase in renal tumors in mid- and high-dose males, including a single carcinoma in a high-dose male, as well as an exacerbation of spontaneous, chronic progressive nephropathy (CPN) in male rats only. The re-evaluation also showed that there were no cellular alterations in the kidney indicative of chemical toxicity at 6 months, 15 months, or 2 years. The evidence linked the occurrence of the predominant basophilic adenomas and foci of atypical tubule hyperplasia (ATH) with the exacerbation of CPN to advanced grades of severity, supporting a mode of action involving quercetin interaction with CPN. This mode of action represents a secondary mechanism for renal tumor development, with no relevance for extrapolation to humans. In addition, the single carcinoma present in the high-dose males, along with 4 other lesions ranging from ATH to adenoma in male and female groups, were considered to have a unique phenotype associated previously with neoplasms of spontaneous and familial origin.

Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin. Publishing Authors By Initials

GC Hard,JC Seely,LJ Betz,SM Hayashi,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred f344 research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred f344 research

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Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Food and chemical toxicology : an international jo

VOLUME: 45

Page Numbers: 600-8

Journal Abbreviation: Food Chem. Toxicol.

ISSN: 0278-6915

DAY: 28

MONTH: 10

YEAR: 2006

Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207483

Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred F344

MESH TERMS: toxicity

Chemical & Substance for Abstract: Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin. Information

Substance Name: Quercetin

Registry Number: 117-39-5

Grant and Affiliation Information for Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin.

AFFILIATION: Private Consultant, 203 Paku Drive, Tairua 3508, New Zealand. gordonhard@mns.com

Country: England

AGENCY: United States NIEHS

GRANT: 1-ES-95435

ACRONYM: ES

MEDLINETA: Food Chem Toxicol

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