Re-assembly of the genome of Francisella tularensis subsp. holarctica OSU18.

Re-assembly of the genome of Francisella tularensis subsp. holarctica OSU18. Research Abstract Details 

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Re-assembly of the genome of Francisella tularensis subsp. holarctica OSU18. Abstract Text:

Francisella tularensis is a highly infectious human intracellular pathogen that is the causative agent of tularemia. It occurs in several major subtypes, including the live vaccine strain holarctica (type B). F. tularensis is classified as category A biodefense agent in part because a relatively small number of organisms can cause severe illness. Three complete genomes of subspecies holarctica have been sequenced and deposited in public archives, of which OSU18 was the first and the only strain for which a scientific publication has appeared. We re-assembled the OSU18 strain using both de novo and comparative assembly techniques, and found that the published sequence has two large inversion mis-assemblies. We generated a corrected assembly of the entire genome along with detailed information on the placement of individual reads within the assembly. This assembly will provide a more accurate basis for future comparative studies of this pathogen.

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Re-assembly of the genome of Francisella tularensis subsp. holarctica OSU18. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: PLoS ONE

VOLUME: 3

Page Numbers: e3427

Journal Abbreviation: PLoS ONE

ISSN: 1932-6203

DAY: 17

MONTH: 10

YEAR: 2008

Re-assembly of the genome of Francisella tularensis subsp. holarctica OSU18. Information

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LANGUAGE: eng

NlmUniqueID: 101285081

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Grant and Affiliation Information for Re-assembly of the genome of Francisella tularensis subsp. holarctica OSU18.

AFFILIATION: Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA.

Country: United States

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MEDLINETA: PLoS ONE

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