RCAI-8, 9, 18, 19, and 49-52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines.

RCAI-8, 9, 18, 19, and 49-52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines. Research Abstract Details 

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RCAI-8, 9, 18, 19, and 49-52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines. Abstract Text:

Ken-ichi Fuhshuku,Naomi Hongo,Takuya Tashiro,Yui Masuda,Ryusuke Nakagawa,Ken-ichiro Seino,Masaru Taniguchi,Kenji Mori,Ken-ichi Fuhshuku,Naomi Hongo,Takuya Tashiro,Yui Masuda,Ryusuke Nakagawa,Ken-ichiro Seino,Masaru Taniguchi,Kenji Mori,

Conformationally restricted analogues of KRN7000, an alpha-d-galactosyl ceramide, were synthesized to examine their bioactivity for mouse natural killer (NK) T cells to produce cytokines. RCAI-8, 9, 51, and 52 are the analogues with a pyrrolidine ring, and RCAI-18, 19, 49, and 50 are those with an azetidine ring. RCAI-18 was shown to be a potent inducer of cytokine production by mouse NKT cells, while RCAI-51 was a moderately active inducer.

RCAI-8, 9, 18, 19, and 49-52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines. Publishing Authors By Initials

K Fuhshuku,N Hongo,T Tashiro,Y Masuda,R Nakagawa,K Seino,M Taniguchi,K Mori,K Fuhshuku,N Hongo,T Tashiro,Y Masuda,R Nakagawa,K Seino,M Taniguchi,K Mori,

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RCAI-8, 9, 18, 19, and 49-52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry

VOLUME: 16

Page Numbers: 950-64

Journal Abbreviation: Bioorg. Med. Chem.

ISSN: 1464-3391

DAY: 10

MONTH: 10

YEAR: 2007

RCAI-8, 9, 18, 19, and 49-52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines. Information

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LANGUAGE: eng

NlmUniqueID: 9413298

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Grant and Affiliation Information for RCAI-8, 9, 18, 19, and 49-52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines.

AFFILIATION: Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2-1, Wako-shi, Saitama 351-0198, Japan.

Country: England

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MEDLINETA: Bioorg Med Chem

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