Rb and hematopoiesis: stem cells to anemia.

Rb and hematopoiesis: stem cells to anemia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Rb and hematopoiesis: stem cells to anemia. Abstract Text:

ABSTRACT: The retinoblastoma protein, Rb, was one of the first tumor suppressor genes identified as a result of the familial syndrome retinoblastoma. In the period since its identification and cloning a large number of studies have described its role in various cellular processes. The application of conditional somatic mutation with lineage and temporally controlled gene deletion strategies, thus circumventing the lethality associated with germ-line deletion of Rb, have allowed for a reanalysis of the in vivo role of Rb. In the hematopoietic system, such approaches have led to new insights into stem cell biology and the role of the microenvironment in regulating hematopoietic stem cell fate. They have also clarified the role that Rb plays during erythropoiesis and defined a novel mechanism linking mitochondrial function to terminal cell cycle withdrawal. These studies have shed light on the in vivo role of Rb in the regulation of hematopoiesis and also prompt further analysis of the role that Rb plays in both the regulation of hematopoietic stem cells and the terminal differentiation of their progeny.

Rb and hematopoiesis: stem cells to anemia. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Rb and hematopoiesis: stem cells to anemia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell division

VOLUME: 3

Page Numbers: 13

Journal Abbreviation:

ISSN: 1747-1028

DAY: 8

MONTH: 09

YEAR: 2008

Rb and hematopoiesis: stem cells to anemia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101251560

Rb and hematopoiesis: stem cells to anemia. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Rb and hematopoiesis: stem cells to anemia. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Rb and hematopoiesis: stem cells to anemia.

AFFILIATION: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology and Stem Cell Program, Children's Hospital Boston, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, 02115, USA. stuart_orkin@dfci.harvard.edu.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cell Div

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Rb and hematopoiesis: stem cells to anemia Related Publications

• Acquired lymphangioma (lymphangiectasis). Report of a case.
• An extended transcriptional network for pluripotency of embryonic stem cells.
• Animal models (spontaneous) for human disease. Experiments of nature.
• Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage.
• CUTANEOUS FORM OF PERIARTERITIS NODOSA--AN ENTITY?
• Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart.
• ETV6-NTRK3 Fusion Oncogene Initiates Breast Cancer from Committed Mammary Progenitors via Activation of AP1 Complex.
• Evaluation of the principles concerned in the management of trauma to the kidney.
• From the Cover: DNA polymorphisms at the BCL11A, HBS1L-MYB, and {beta}-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.
• Funding for Canadian health care research.
• Granulomatous perivasculitis in Crohn's disease.
• Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut.
• METHEMOGLOBINEMIA ASSOCIATED WITH THE INGESTION OF DIASONE.
• MICROCIRCULATORY EFFECTS OF ANESTHESIA IN SHOCK.
• Mastocytosis in animals.
• Methemoglobinemia associated with the ingestion of Diasone.
• Molecular genetics of chronic granulomatous disease.
• Potential health risks of complementary alternative medicines in HIV patients.
• Rb and hematopoiesis: stem cells to anemia.
• Requirement of Nanog dimerization for stem cell self-renewal and pluripotency.
• Site-directed, virus-free, and inducible RNAi in embryonic stem cells.
• Subspecialties in family medicine: a question of values.
• Symposium on skin diseases common to man and animal. Introductory comments.
• The increased pathogenicity of Bacillus lactis aerogenes in urinary tract infections.
• Today's scabies.
• [Prolapse of fibromyxoma of the urinary bladder through the urethra in a 1-year-old boy.]