[Rational use of catecholamines and inotropes]

[Rational use of catecholamines and inotropes] Research Abstract Details 

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[Rational use of catecholamines and inotropes] Abstract Text:

B Hewing,K Stangl,

Acute heart failure syndromes (AHFS) are a growing health problem in Western Countries. Standard treatment includes vasodilators and diuretics, however, the subgroup of patients with AHFS and low cardiac output state represents a special therapeutic challenge that is complicated by high in-hospital and post-discharge mortality and by requiring additional i. v. inotropic support. The current inotropes in use are adrenoreceptor agonists (dopamine, dobutamine, norepinephrine, epinephrine), phosphodiesterase III inhibitors (milrinone, enoximone), and Ca2+ sensitizers (levosimendane). While most inotropes yield short-term haemodynamic improvements, they are associated with increased myocardial oxygen consumption, (supra-) ventricular arrhythmias and possibly increased post-discharge mortality. This review highlights current inotropes used in the treatment of AHFS and introduces new drug developments including myosin activators and Na+/K+ ATPase inhibitors.

[Rational use of catecholamines and inotropes] Publishing Authors By Initials

B Hewing,K Stangl,

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[Rational use of catecholamines and inotropes] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pneumologie (Stuttgart, Germany)

VOLUME: 61

Page Numbers: 700-8

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ISSN: 1438-8790

DAY: 10

MONTH: 10

YEAR: 2007

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LANGUAGE: ger

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AFFILIATION: Universitätsmedizin Berlin, Medizinische Klinik und Poliklinik mit Schwerpunkt Kardiologie und Angiologie, Charité Campus Mitte, Berlin.

Country: Germany

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MEDLINETA: Pneumologie

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